Figure 1: Homocysteine-folate biochemical pathway (27). SHMT: Serine hydroxymethyltransferase, MTHFD: Methylenetetrahydrofolate dehydrogenase, MTHFR: Methylenetetrahydrofolate reductase, MTRR: Methionine synthase reductase, MTR: Methionine synthase, CBS: Cystathionine β synthase, CTH: Cystathionine γ lyase, AHCY: Adenosylhomocysteinase, MAT2B: Methionine adenosyltransferase, DNMT1: DNA methyltransferase