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 Indian J Med Microbiol  
 

Figure 2: Influence of SOX2, OCT4 and NANOG in lineage selection of pluripotent stem cells. In lineage selection, ESCs lose their pluripotency to differentiate into NE or mesoendodermal lineage under the influence of differential expression of transcription factors, i.e., SOX2, OCT4 and NANOG. Other factors such as Wnt-3a, actin, fibroblast growth factor and retinoic acid have positive and negative control in the aforementioned selection process

Figure 2: Influence of SOX2, OCT4 and NANOG in lineage selection of pluripotent stem cells. In lineage selection, ESCs lose their pluripotency to differentiate into NE or mesoendodermal lineage under the influence of differential expression of transcription factors, i.e., SOX2, OCT4 and NANOG. Other factors such as Wnt-3a, actin, fibroblast growth factor and retinoic acid have positive and negative control in the aforementioned selection process