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 Indian J Med Microbiol  
 

Figure 2: Schematic representation of collagen synthesis starting from the nuclear transcription of the collagen genes, mRNA processing, ribosomal protein synthesis (translation) and posttranslational modifications, secretion and the final steps of fibril formation. (SP: Signal peptidase; GT: Hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase; LH: Lysyl hydroxylase; PH: Prolylhydroxylase; OTC: Oligosaccharyl transferase complex; PDI: Protein disulphide isomerase; PPI: Peptidyl-prolyl cis-trans-isomerase; NP: Procollagen N-proteinase; CP: Procollagen C-proteinase; LO: Lysyl oxidase; HSP47: Heat shock protein 47, colligin1). (Courtesy K. Gelse et al./Advanced Drug Delivery Reviews 55 (2003) 1531-1546)

Figure 2: Schematic representation of collagen synthesis starting from the nuclear transcription of the collagen genes, mRNA processing, ribosomal protein synthesis (translation) and posttranslational modifications, secretion and the final steps of fibril formation. (SP: Signal peptidase; GT: Hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase; LH: Lysyl hydroxylase; PH: Prolylhydroxylase; OTC: Oligosaccharyl transferase complex; PDI: Protein disulphide isomerase; PPI: Peptidyl-prolyl cis-trans-isomerase; NP: Procollagen N-proteinase; CP: Procollagen C-proteinase; LO: Lysyl oxidase; HSP47: Heat shock protein 47, colligin1). (Courtesy K. Gelse <i>et al</i>./Advanced Drug Delivery Reviews 55 (2003) 1531-1546)