ONLINE ONLY ARTICLES - ORIGINAL ARTICLE
Year : 2020 | Volume
: 24 | Issue : 2 | Page : 400-
Analysis of octamer-binding transcription factor-4 expression in oral leukoplakia
Anand Siddappa Tegginamani1, Vanishree Halasagundhi Shivakumar1, Thomas George Kallarakkal2, Siti Mazlipah Ismail2, Mannil Thomas Abraham3, Ahmad Termizi Bin Zamzuri1
1 Faculty of dentistry SEGi University Kota kamansara, Klang, Malaysia
2 Faculty of Dentistry, University of Malaya, Klang, Malaysia
3 Hospital Tengku Ampuan Rahimah, Klang, Malaysia
Background: Oral potentially malignant disorders have a risk for malignant transformation but are difficult to reliably identify and predict which patients are at the risk for malignant transformation. OCT4 has been hypothesized to play a key oncogenic driver in a variety of solid tumors. A deeper understanding of the aberrant molecular pathways which lead to carcinogenesis needs to be identified by the potential markers.
Aims: To assess the OCT4 stemness factor in oral leukoplakia for its potential risk to malignant transformation.
Settings and Design: 20 cases of oral leukoplakia were obtained from archives at Oral Cancer Research & Coordinating center (OCRCC) Malaysia Subjects and Methods: 20 cases of oral leukoplakia were assessed by OCT4 immunohistochemically. Oral squamous cell carcinoma was used as a control.
Result: no expression of OCT 4 was observed in any cases of oral leukoplakia.
Conclusion: The molecular mechanisms of Oct4 regulation and in particular of its switch on and off in tissues depends upon its microenvironment, which makes it challenging in fundamental and applied research fields of regenerative medicine and cancer therapy. It's better that patients should undergo multiple biopsies for the early detection of malignant transformation with close follow-up during the first two to three years, a large amount of work remains to be done with multi-marker panel investigation, as cure rates have remained constant over three decades.
Anand Siddappa Tegginamani
Faculty of Dentistry, SEGi University Kota Damansara, Petaling Jaya
|How to cite this article:|
Tegginamani AS, Shivakumar VH, Kallarakkal TG, Ismail SM, Abraham MT, Bin Zamzuri AT. Analysis of octamer-binding transcription factor-4 expression in oral leukoplakia.J Oral Maxillofac Pathol 2020;24:400-400
|How to cite this URL:|
Tegginamani AS, Shivakumar VH, Kallarakkal TG, Ismail SM, Abraham MT, Bin Zamzuri AT. Analysis of octamer-binding transcription factor-4 expression in oral leukoplakia. J Oral Maxillofac Pathol [serial online] 2020 [cited 2021 Sep 26 ];24:400-400
Available from: https://www.jomfp.in/article.asp?issn=0973-029X;year=2020;volume=24;issue=2;spage=400;epage=400;aulast=Tegginamani;type=0