Journal of Oral and Maxillofacial Pathology

: 2012  |  Volume : 16  |  Issue : 3  |  Page : 473--474

Epithelial myoepithelial carcinoma

Nagarajan Lavanya, Elizabeth Joshua, Kannan Ranganathan 
 Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
Nagarajan Lavanya
Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, Tamil Nadu

How to cite this article:
Lavanya N, Joshua E, Ranganathan K. Epithelial myoepithelial carcinoma.J Oral Maxillofac Pathol 2012;16:473-474

How to cite this URL:
Lavanya N, Joshua E, Ranganathan K. Epithelial myoepithelial carcinoma. J Oral Maxillofac Pathol [serial online] 2012 [cited 2021 Apr 14 ];16:473-474
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 Case History

A 78-year-old male complained of postextraction pain in right lower jaw; 46, 47, 48 had been extracted 4 days as they were mobile and painful for the past 6 months. Extra orally, there was a 3 × 4 cm sized firm, nontender swelling in the right submandibular region. A single submandibular node was palpable and fixed. Intra orally, there was a tender ulcer in the floor of the mouth in the right lingual vestibule with central yellow slough.


Ulcerated nonkeratinising surface epithelium in association with an inflamed fibrovascular connective tissue exhibiting infiltrating islands and nests of neoplastic epithelial cells [[Figure 1] surface epithelium not seen in the picture].{Figure 1}

Variably sized duct like structures and microcystic areas were seen within the islands and nests [Figure 1] and [Figure 2].{Figure 2}

Duct like structures were lined with two layers of cells; luminal cuboidal cells and abluminal (basal) of layer of clear cells [Figure 2], [Figure 3], [Figure 4].{Figure 3}{Figure 4}

The inner layer of cuboidal cells were similar to epithelium of normal intercalated ducts, with eosinophilic cytoplasm and nucleus exhibiting fine chromatin. This was surrounded by an abluminal (basa) l layer of larger cells with clear cytoplasm and basophilic round to oval nuclei [Figure 2], [Figure 3], [Figure 4].

Dense hyalinized basement membrane of variable thickness surrounding the islands of neoplastic epithelial cells [Figure 4].

 Differential Diagnosis

Epithelial Myoepithelial carcinoma.Clear cell variant of - Mucoepidermoid carcinoma, oncocytic lesions, mixed tumor.Polymorphous low-grade adeno carcinoma.Clear cell carcinoma not otherwise specified/hyalinising clear cell carcinoma.Sebaeceous adenoma/carcinoma.Metastatic renal cell carcinoma.


Basal cells were positive for both S-100 and p63. However, p63 staining was more uniform and confined to the basal layer. [[Figure 5] and [Figure 6]; S-100, p63, respectively] confirming basal cells as myoepithelial cells.{Figure 5}{Figure 6}


Epithelial myoepithelial carcinoma.