Journal of Oral and Maxillofacial Pathology

: 2012  |  Volume : 16  |  Issue : 3  |  Page : 470--472


Shweta Jaitley 
 Department of Oral Pathology and Microbiology, KD Dental College and Hospital, Mathura, Uttar Pradesh, India

Correspondence Address:
Shweta Jaitley
Department of Oral Pathology and Microbiology, KD Dental College and Hospital, Mathura, Uttar Pradesh

How to cite this article:
Jaitley S. Angiosarcoma.J Oral Maxillofac Pathol 2012;16:470-472

How to cite this URL:
Jaitley S. Angiosarcoma. J Oral Maxillofac Pathol [serial online] 2012 [cited 2021 Apr 14 ];16:470-472
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 Case Details

A 38-year-old female patient reported with a bluish-red-colored proliferative growth present on the left side of posterior mandibular gingiva.

 Histopathological Features

Stratified squamous epithelium exhibiting ulceration and formation of fibrinopurulent membrane [Figure 1].{Figure 1}

Highly vascular connective tissue exhibiting numerous blood capillaries and areas of endothelial cell proliferation. Some sinusoidal capillaries are also seen [Figure 2].{Figure 2}

Irregular infiltrative growth pattern with anastomosing blood capillaries containing intraluminal spindle shaped tumor cells. Multi-layering of epithelioid endothelial cells with extravasated red blood cells are also seen [Figure 3].{Figure 3}

Endothelial cells forming intraluminal plaques in the background of loosely arranged connective tissue stroma [Figure 4].{Figure 4}

Malignant endothelial cells arranging themselves to form lumen within the existing vascular lumina [Figure 5].{Figure 5}

Sheets of epithelioid endothelial cells exhibiting vesicular nucleus, cleaved nuclear contours and intracytoplasmic vacuoles along with mitotic figures. Myxoid areas are seen [Figure 6].{Figure 6}

Endothelial cells show nuclear pleomorphism with prominent and multiple nucleoli. ≥10 mitotic figures/HPF and many abnormal mitotic figures are present [Figure 7].{Figure 7}

Some areas of necrosis seen. Intense stromal inflammation with the predominance of eosinophils present along with some extravasated RBCs [Figure 8].{Figure 8}

 Differential Diagnosis

Epithelioid hemangioma: Well-formed canalized vessels and lobular architecture. Stromal inflammation is present but no overt vessel formation.

Epithelioid hemangioendothelioma: Shows smaller tumor cells arranged in cords, strands, or nests showing vesicular nucleus and inconspicuous nucleolous. Lacks multilayering of vascular channels and mitotic figures are not so frequent.

Reactive papillary endothelial hyperplasia: Fibrinoid micronodules evident. No endothelial atypia or multilayering present and mitosis are infrequent.

Epithelioid sarcoma: Commonly occurs in distal extremities. Shows nodular arrangement of tumor cells with areas of central necrosis. Nuclear pleomorphism is moderate.

Sinusoidal hemangioma: Although mild nuclear pleomorphism is present, distinction can be made by presence of monolayered endothelium and each narrow vessel wall also contains delicate layer of subendothelial pericytes.

Spindle cell hemangioendothelioma: Cavernous spaces lined by single layer of bland endothelial cells. Nuclear atypia is rare.

Tufted angioma: Multiple lesions seen rarely in adults. Poorly canalized small vessels with bland endothelial cells.

Malignant endovascular papillary angioendothelioma: Usually affects children. It is characterized by hobnail-like endothelial cells within the dilated spaces.

 Final Diagnosis

Epithelioid angiosarcoma.


Vascular tumours may sometimes mimic just a reactive lesion clinically. They may also show some histopathological features of a reactive lesion. Therefore, thorough histopathological examination and observation of the above mentioned features would aid in correct diagnosis and further treatment of more aggressive vascular malignancies like angiosarcoma.