Journal of Oral and Maxillofacial Pathology

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 16  |  Issue : 3  |  Page : 338--342

Sister chromatid exchanges in smokers and smokers with alcohol habit


J Vijay Kumar1, TR Saraswathi2, K Ranganathan3, KM Umadevi3, Elizabeth Joshua3, T Rooban3 
1 Department of Oral and Maxillofacial Pathology, Panineeya Institute of Dental Sciences, Hyderabad, Andhra Pradesh, India
2 Department of Oral and Maxillofacial Pathology, Vishnu Dental College, Hyderabad, Andhra Pradesh, India
3 Department of Oral and Maxillofacial Pathology, Ragas Dental College, Hyderabad, Andhra Pradesh, India

Correspondence Address:
J Vijay Kumar
Department of Oral and Maxillofacial Pathology, Panineeya Mahavidyalaya Institute of Dental Sciences, Road No 5, Kamalanagar, Dilshuknagar, Hyderabad, Andhra Pradesh
India

Aim : Sister chromatid exchange (SCE) test is a sensitive, biomarker of genotoxic substances. The present study was conducted to observe the frequency of SCEs in peripheral blood lymphocytes of 30 males with and without the habit of cigarette smoking and alcohol consumption. Materials and Methods : Subjects for this study were males aged between 25-50 years and were selected from the students, employees and the patients attending the outpatient department of Ragas dental college and Hospital, Chennai. Results: Controls, smokers, and smokers with alcohol habit were divided into two age groups as ≤30 years and ≥30 years. In controls the mean frequency of SCEs/cell in ≤30 years and ≥30 year«SQ»s age group was 5.80 and 6.05, respectively. In Smokers SCEs/cell in ≤30 years and ≥30 year«SQ»s age group was 7.7 and 8.8, respectively. In Smokers with alcohol habit SCEs/cell in ≤30 years and ≥30 years age group was 10.1 and 12.8, respectively. Conclusions: In this study, the duration of the smoking habit has shown a positive correlation with the mean SCE frequency. Whereas, frequency of the habit did not show any influence on the SCE levels. In smokers with alcohol habit, both the duration and frequency of their smoking habit has shown a significant effect on the SCE levels suggesting a synergistic effect of alcohol and smoking leading to excessive DNA damage.


How to cite this article:
Kumar J V, Saraswathi T R, Ranganathan K, Umadevi K M, Joshua E, Rooban T. Sister chromatid exchanges in smokers and smokers with alcohol habit.J Oral Maxillofac Pathol 2012;16:338-342


How to cite this URL:
Kumar J V, Saraswathi T R, Ranganathan K, Umadevi K M, Joshua E, Rooban T. Sister chromatid exchanges in smokers and smokers with alcohol habit. J Oral Maxillofac Pathol [serial online] 2012 [cited 2021 Apr 14 ];16:338-342
Available from: https://www.jomfp.in/article.asp?issn=0973-029X;year=2012;volume=16;issue=3;spage=338;epage=342;aulast=Kumar;type=0