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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
CASE REPORT Table of Contents   
Year : 2021  |  Volume : 25  |  Issue : 4  |  Page : 22-26
Clear-cell variant of oral squamous cell carcinoma: A rare entity


Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospital, SIMATS University, Chennai, Tamil Nadu, India

Correspondence Address:
Pratibha Ramani
Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospital, SIMATS University, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_295_20

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Clear-cell variant of oral squamous cell carcinoma is an extremely rare entity in the maxillofacial region. We report a case of 42-year-old female who presented with a soft-tissue growth with erythematous and nonscrapable irregular white patches on the left alveolar mucosa for the past 3 months. Histopathologic examination showed lobules and sheets of clear cells with features of malignancy extending from the surface epithelium. Periodic acid–Schiff and mucicarmine stains showed a negative reaction. Immunohistochemical study using antibody for pan-cytokeratin revealed intense positivity and negative for the markers such as S-100, smooth muscle actin and CD 117.


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