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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2020  |  Volume : 24  |  Issue : 3  |  Page : 530-535
Extracellular matrix metalloproteinase inducer expression in histological grades of oral squamous cell carcinoma – An immunohistochemical study


1 Indian Cancer Society, Mumbai, Maharashtra, India
2 Department of Oral and Maxillofacial Pathology, MGV'S KBH Dental College and Hospital, Nashik, Maharashtra, India
3 Department of Conservative Dentistry and Endodontics, SMBT Institute of Dental Sciences, Nashik, Maharashtra, India

Correspondence Address:
Nilima Prakash
Department of Oral and Maxillofacial Pathology, MGV'S KBH Dental College and Hospital, Nashik, Maharashtra,
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_26_20

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Background: Oral squamous cell carcinoma (OSCC) is the most common type of head-and-neck cancer. It is a complex and relentless malignancy prone to local invasion and dissemination. An insight into the molecular alterations associated with metastasis will provide critical insights into the fundamental mechanisms underlying its progression and further contribute to improvements in the clinical management of H and N cancer patients. Hence, identifying specific biomarkers would pave the way for early detection and prognosis of OSCC. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a membrane-bound glycoprotein found on the surface of tumor cells. It plays a central role in the promotion of tumor invasion, progression and metastasis as it upregulates matrix metalloproteinases secreted from adjacent fibroblasts. There is a paucity of studies on the expression of EMMPRIN in OSCC. Objectives: The aim is to assess the immunohistochemical expression of EMMPRIN in OSCC and to compare it with the clinicopathological parameters and histological grades of OSCC. Materials and Methods: Thirty histopathologically diagnosed cases of OSCC were included in the study. The slides were immunohistochemically analyzed for EMMPRIN expression and correlated with the clinicopathological parameters and histological grades of OSCC. Results: EMMPRIN expression was noted in all 30 cases of OSCC. Strong EMMPRIN expression was noted in the advanced clinical stages of OSCC. Higher histological grades of OSCC exhibited strong EMMPRIN expression. Conclusion: EMMPRIN overexpression indicates that this protein could be used as an important biological prognostic marker to identify high-risk OSCC patients.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007