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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2020  |  Volume : 24  |  Issue : 3  |  Page : 517-522
Evaluation of antifungal activity of mint, pomegranate and coriander on fluconazole-resistant Candida glabrata

Department of Oral and Maxillofacial Pathology and Microbiology, SRM Dental College, Chennai, Tamil Nadu, India

Correspondence Address:
Lekshmy Jayan
Department of Oral and Maxillofacial Pathology and Microbiology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jomfp.JOMFP_355_19

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Introduction: Antifungal resistance shown by different species of Candida has affected the management of candidiasis drastically. This has led to the need for newer safer therapeutic alternatives for their management. Phytochemical agents have been long known to possess numerous medicinal activities. Aim: The aim of this study was to evaluate the efficacy and resistance of fluconazole and to compare the antifungal effects of Coriandrum sativum, Mentha piperita and Punica granatum in Candida glabrata. Materials and Methods: The organism was inoculated into a specific medium, and extracts are added at serial dilutions and incubated to evaluate the zone of inhibition. Results: All the three extracts showed statistically significant and superior antifungal activity to fluconazole in fluconazole-resistant C. glabrata. Conclusion: Although the extracts showed superior antifungal activity in resistant C. glabrata strains, further studies are needed to evaluate these extracts in patients to see if their efficacy is impeded by any systemic or local factors in the body.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007