Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contact Us Login 
An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

Year : 2020  |  Volume : 24  |  Issue : 2  |  Page : 400-401
The efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide-induced squamous cell carcinoma of the tongue in rats

1 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Başkent University, İstanbul, Turkey
2 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Medipol University, İstanbul, Turkey
3 Department of Pathology, Faculty of Medicine, Başkent University, İstanbul, Turkey
4 Pathology Laboratory, Council of Forensic Medicine, Ankara Group Chairmanship, İstanbul, Turkey
5 Animal Research Center, Başkent University, İstanbul, Turkey

Correspondence Address:
Secil Cubuk
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, 11 Sokak No: 26 Bahçelievler, Ankara 06490
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jomfp.JOMFP_88_18

Rights and Permissions

Aims: The aim of this study to investigate the efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinogenesis of the tongue in rats. Subjects and Methods: The sample was composed of 27 male Sprague Dawley rats that received 50 ppm 4NQO for 20 weeks in drinking water. Group 1 (n = 9) was treated with 50 mg/kg/day propranolol for 20 weeks, Group 2 (n = 9), after carcinogenesis inducement for 20 weeks, received propranolol (50 mg/kg/day) for 2 weeks and Group 3 (n = 9) received no treatment. At the end of the experimental stage, the tongue specimens were evaluated under a light microscope and categorized as low- or high-risk lesions according to a binary system. Statistical Analysis Used: The statistical comparison was performed with a likelihood ratio test. Results: Histopathological analysis revealed the risk of malignant transformation rates as 33.3% in Group 1, 55.5% in Group 2 and 77.8% in Group 3; however, the difference between the groups was not statistically significant (P > 0.05). Conclusion: The results of the study suggest that propranolol has a tendency to preventive effect against carcinogenesis.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded54    
    Comments [Add]    

Recommend this journal


Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007