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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
REVIEW ARTICLE Table of Contents   
Year : 2020  |  Volume : 24  |  Issue : 2  |  Page : 374-382
The effect of Vitamin C on melanin pigmentation – A systematic review


1 Department of Periodontics, Dr GD Pol Foundation's YMT Dental College, Kharghar, Sector - 4, Navi Mumbai, Maharashtra, India; PhD Student
2 Department of Oral Pathology & Microbiology, Bharati Vidyapeeth Deemed to be University, Dental College & Hospital, Satara Road, Katraj, Dhankawadi, Pune, Maharashtra, India

Correspondence Address:
Rizwan M Sanadi
Bharati Vidyapeeth Deemed to be University, Dental College and Hospital, Satara Road, Katraj, Dhankawadi, Pune - 411 043, Maharashtra; Department of Periodontics, Dr. G D Pol Foundation’s, YMT Dental College, Kharghar, Sector – 4, Navi Mumbai - 410 210, Maharashtra, India

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_207_20

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Vitamin C, also known as ascorbic acid, is used as a treatment modality in depigmentation of hyperpigmented spots on the skin and gingiva. This systematic review discusses the studies conducted to assess the effect of Vitamin C on melanin pigmentation. The primary objective was to evaluate the effect of Vitamin C on melanin pigmentation. The secondary objective was to analyze the effect of Vitamin C administration on melanin pigmentation. An electronic database search was conducted from the following databases: PubMed, EBSCOhost, ScienceOpen, EMBASE and Google Scholar. Randomized controlled trials, experimental studies, case–control studies and cohort studies published in peer-reviewed journals in English language were included. Case reports, case series, animal model studies, in vitro studies, studies where Vitamin C was used along with other agents and unpublished research were excluded. Out of 22,580 studies, only 7 studies satisfied the selection criteria. Data extraction sheet was prepared, and the studies were analyzed. Out of the 7 studies analyzed, 1 was a randomized controlled trial and 6 were experimental studies. Vitamin C has been used widely as a depigmenting agent in dermatology. However, there are limited studies conducted on the use of Vitamin C for gingival depigmentation.


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