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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

Year : 2018  |  Volume : 22  |  Issue : 3  |  Page : 444
Experimental model of oral ulcer in mice: Comparing wound healing in three immunologically distinct animal lines

1 Department of Dentistry, Unichristus, Fortaleza, Ceará, Brazil
2 Department of Dental Clinic, Sector of Oral Pathology, Universidade Federal Do Ceará, Fortaleza, Ceará, Brazil
3 Department of Dentistry, Unichristus; Department of Dental Clinic, Sector of Oral Pathology, Universidade Federal Do Ceará, Fortaleza, Ceará, Brazil

Correspondence Address:
Paulo Goberlânio de Barros Silva
Department of Dentistry, Unichristus, João Adolfo Gurgel Street, 133 Papicu, 60160-230, Fortaleza, Ceará
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jomfp.JOMFP_144_17

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Background: The oral wound healing is dependent of immune participation and the absence or augment of one specific immune profile can delayed wound healing. Objectives: So, the objective of this study was t evaluate the wound healing of oral traumatic ulcer (OTU) in cheek mucosa of swiss, balb/c and c57bl6J mice. Materials and Methods: A total of 144 mice (25-30g) were distributed in three groups: swiss (n = 48), balb/c (n = 48) and c57bl/6j (n = 48). An OTU was performed using a dermatological punch in left cheek mucosa. The animals were euthanized daily (n = 6/group/day by 8 days) for evaluation of the ulcer area, weight loss and histological analysis. Results: There are no differences between ulcer area in three groups; however only swiss group showed total wound healing. Swiss group showed weight loss in 2nd and 3rd days recovering the body mass in 4th day (P < 0.01). Balb/c group showed the greater weight loss (P < 0.05) and c57bl/6j did not show body mass variation (P = 0.258). Histologically swiss group was the only group that showed total reepithelization (P < 0.001). Balb/c (P = 0.022) and c57bl/6j (P < 0.001) showed decrease in histological scores, chronic inflammation on the 8th day. Actinomyces was significantly more observed in surface of OTU of balb/c. Conclusion: Balb/c mice showed high infection of OTU surface delaying wound healing, and greater weight loss. C57bl/6J mice showed low infection of OTU, but not healing along the eight days. Only the Swiss mice showed wound healing of OTU.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007