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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
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Year : 2017  |  Volume : 21  |  Issue : 2  |  Page : 260-263
Current concepts of pemphigus with a deep insight into its molecular aspects


Department of Oral Pathology and Microbiology, Mamata Dental College, Khammam, Telangana, India

Correspondence Address:
Jayakiran Madala
Department of Oral Pathology and Microbiology, Mamata Dental College, Khammam - 507 002, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_143_17

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Pemphigus vulgaris is an autoimmune bullous disease involving both the skin and mucosal areas, which is characterized by intraepithelial flaccid blisters and erosions. The pathogenesis of this disease is not yet completely established, but novel intuitions into its pathogenesis have recently been published. An unanswered question in its pathophysiology is the mechanism of acantholysis or loss of keratinocyte cell adhesion. Acantholysis seems to result from a communal action of autoantibodies against numerous keratinocyte self-antigens, of which desmogleins 1 and 3, desmocollins and nondesmosome components, such as the mitochondrion, might take part in the disease initiation. Lately, apoptosis was described as a possible underlying mechanism of acantholysis. Likewise, apoptolysis is assumed to be the association between suprabasal acantholytic and cell death pathways. Hence, the present review focuses on the current concepts in the pathogenesis of the pemphigus in a nutshell.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
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