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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
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Year : 2017  |  Volume : 21  |  Issue : 1  |  Page : 82-86
Phenotypic switch: The enigmatic white-gray-opaque transition system of Candida albicans


1 Department of Oral Pathology and Microbiology and Forensic Odontology, School of Dental Sciences, Krishna Institute of Medical Sciences, Karad, Maharashtra, India
2 Department of Pedodontics and Preventive Dentistry, School of Dental Sciences, Krishna Institute of Medical Sciences, Karad, Maharashtra, India
3 Department of Oral and Maxillofacial Surgery, School of Dental Sciences, Krishna Institute of Medical Sciences, Karad, Maharashtra, India

Correspondence Address:
Sushma Basavaraj Bommanavar
Department of Oral and Maxillofacial Pathology, School of Dental Sciences, Krishna Institute of Dental College and Hospital, Karad, Maharastra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.203781

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Candida albicans represents the most common commensal and opportunistic fungal pathogen colonizing humans. As a member of the normal microflora, it is present on the skin and the mucous membranes of the upper respiratory tract, gastrointestinal tract and female genital tracts. It is therefore not transmitted. It lies in wait for a change in some aspect of the host physiology that normally suppress growth and invasiveness through an enigmatic phenomenon called Phenotypic Switch System or White-Opaque Transition. This system involves reversible and heritable switching between alternative cellular phenotypes. White–opaque switching in Candida albicans was first discovered in 1987. This was initially identified in strain WO-1. Switching has been demonstrated to occur at sites of infection and to occur between recurrent episodes of infection in select cases esp. AIDS and diabetes.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007