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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2016  |  Volume : 20  |  Issue : 2  |  Page : 173-177
Evaluation of natural killer cell (CD57) as a prognostic marker in oral squamous cell carcinoma: An immunohistochemistry study


1 Department of Oral and Maxillofacial Pathology, Dr. B. R. Ambedkar Institute of Dental Sciences and Hospital, Patna, Bihar, India
2 Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College, Wardha, Maharashtra, India

Correspondence Address:
Rashmi Agarwal
Total Dental Care, 4261/3, Jai Mata Market, Tri Nagar, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.185933

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Objectives: Natural killer (NK) cells are important effector lymphocytes. NK cells are considered to represent innate immune system. NK cells target and kill aberrant cells such as virally infected and tumorigenic cells. The purpose of this study was to assess the expression of CD57 in oral squamous cell carcinoma (OSCC) and to correlate the expression of CD57 with 3 years survival in patients with OSCC. Materials and Methods: About 100 histopathologically diagnosed cases of OSCC of various grades were divided into two groups, i.e., Group I (dead patients) and Group II (live patients) from the archives of Department of Oral Pathology and Microbiology. CD57 was detected in these tissues by immunohistochemistry. Result: The results were analyzed using Spearman's correlation coefficient and students unpaired t-test. The mean CD57 labeling index in Group II was significantly higher than that found in Group I (P = 0.000). There was a significant correlation (P = 0.00) in the mean CD57 levels between Groups I and II and prognosis of patient. Conclusion: CD57 could be a good prognostic marker for OSCC patients.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007