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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2014  |  Volume : 18  |  Issue : 4  |  Page : 60-65
A comparative study of oral candidal species carriage in patients with type1 and type2 diabetes mellitus

1 Department of Oral Pathology and Microbiology, Attavara Balakrishna Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore, Karnataka, India
2 Department of Oral Pathology and Microbiology, Parvathagouda Mallannagouda Nadagouda Memorial Dental College and Hospital, Bagalkot Karnataka, India
3 Department of Oral Medicine and Radiology, Parvathagouda Mallannagouda Nadagouda Memorial Dental College and Hospital, Bagalkot, Karnataka, India
4 Department of Biochemistry, Srinivas Institute of Medical Sciences and Research Centre, Srinivas Nagar, Mukka, Mangalore, Karnataka, India

Correspondence Address:
Mangesh P Shenoy
Department of Oral Pathology and Microbiology, A. B. Shetty Memorial Institute of Dental Sciences,Deralakatte, Mangalore 575 018, Karnataka,
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.141361

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Context: Diabetes mellitus can have profound effects upon the oral tissues especially in patients with poor glycemic control being prone to severe and/or recurrent infections particularly candidiasis. The main aim was to study the association between Type 1 and Type 2 diabetes mellitus and candidal carriage. Materials and Methods: The study design comprised of previously diagnosed 30 patients each with type 1 diabetes mellitus (Group A) and type 2 diabetes mellitus (Group B) and 30 age-, sex- and dental status-matched healthy non-diabetic individuals as controls (Group C). The saliva samples were collected and inoculated onto Sabouraud dextrose agar (SDA) and chromogenic agar culture medium. Candidal colony forming units per ml (CFU/ml) values were determined. Statistical Analysis: Data were analyzed by χ2 test, Mann-Whitney U-test, Spearman's rank correlation and Karl Pearson's correlation coefficient. Results: Data analysis showed statistically significant higher positive candidal growth in Group A and Group B when compared to Group C. The CFU/ml values were significantly higher in Groups A and B as compared with Group C. Significant positive correlation of CFU/ml with fasting blood sugar level and HbA1c% in both Groups A and B was seen. Oral signs and symptoms observed in diabetics were dry mouth, burning sensation, fissuring and atrophic changes of tongue and erythematous areas, which positively correlated with candidal load. Conclusion: The glycemic control status of the diabetic patients may directly influence candidal colonization. The quantitative and biochemical characterization allows better insight into the study of association of diabetes mellitus and candida.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007