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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
  Table of Contents    
CASE REPORT  
Year : 2013  |  Volume : 17  |  Issue : 3  |  Page : 443-446
 

Diagnosis and management of bilateral nasolabial cysts


1 Department of Oral Pathology, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India
2 Department of Periodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India

Date of Web Publication17-Jan-2014

Correspondence Address:
Rajkumar Parwani
A-306 Staff Quarters, Modern Dental College Campus, Bijasan Road, Gandhinagar, Indore - 453 112, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.125217

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   Abstract 

Nasolabial cysts are painless, submucosal, non-odontogenic jaw cysts presenting as soft tissue swellings in the maxillary anterior mucolabial fold lateral to midline, leading to elevation of nasal ala. Present case documents bilateral nasolabial cysts in a 69-year-old Asian female patient. In the present case, extraoral swelling of maxillary lip and elevation of nasal ala was observed on right side of the face. Intraorally, soft and fluctuant bilateral cysts were observed. Straw-colored fluid was aspirated from the right cyst. Radiographically, erosion of bone in a "cupping" fashion was observed in the region of left cyst. The cysts were enucleated using intraoral approach. Histopathology of the right-sided cyst revealed a cystic cavity lined by stratified squamous cells along with a few mucosal cells. At few places, stratified squamous and pseudostratified columnar epithelia with many cilia and goblet cells were also evident. Capsule was loosely arranged with fibrous tissue and chronic inflammatory infiltrate. Left-sided cystic specimen showed two or more layered stratified squamous lining epithelium with thin capsule. Diagnosis of bilateral nasolabial/nasoalveolar cysts was confirmed.


Keywords: Non-odontogenic cyst, nasoalveolar, nasolabial


How to cite this article:
Parwani R, Parwani S, Wanjari S. Diagnosis and management of bilateral nasolabial cysts. J Oral Maxillofac Pathol 2013;17:443-6

How to cite this URL:
Parwani R, Parwani S, Wanjari S. Diagnosis and management of bilateral nasolabial cysts. J Oral Maxillofac Pathol [serial online] 2013 [cited 2021 Jul 24];17:443-6. Available from: https://www.jomfp.in/text.asp?2013/17/3/443/125217



   Introduction Top


Nasolabial cyst is a rare developmental/fissural cyst that may involve bone secondarily. [1] Intraorally, it presents as a soft-tissue swelling of the maxillary anterior mucolabial fold, lateral to midline leading to obliteration of the nasolabial fold. It is submucosal and extraosseous, spreads in the labial sulcus and expands all the soft tissues outwards. [2] Extraorally, it appears as a swelling between the upper lip and nasal aperture causing elevation of nasal ala. [3] The terms nasolabial and nasoalveolar cysts have been used synonymously, as these are similar cysts with the only difference that the former is a lesion located entirely within the soft tissues and the latter causes maxillary alveolar bone erosion. [4],[5] A case report of a female patient with such bilateral cysts is presented here.


   Case Report Top


A 69-year-old female reported to the Dental college with a chief complaint of an extraoral swelling on the right side of her upper lip and elevation of the alar base [Figure 1]a since 7-8 months. History of present illness revealed that the swelling had increased in size since its initiation but was not associated with any pain, drainage through oral/nasal cavity or difficulty in breathing through nasal obstruction. Furthermore, there was no history of dacryocystitis/watery eyes but there was a swelling intraorally corresponding to this extraoral swelling which was obliterating the labial vestibule on that side.

Intraoral examination revealed bilateral smooth, soft, fluctuant masses lateral to the central incisor teeth in the maxillary labial vestibule. The right-sided mass was well-defined [Figure 1]b and measured approximately 2 × 3 cm and left-sided mass measured 1.5 × 1.5 cm when palpated bimanually. Aspiration biopsy from right-sided mass revealed straw-colored fluid [Figure 1]c.
Figure 1: (a) Clinical picture showing extraoral swelling and elevation of alar base on the right side. (b) Clinical picture showing intraoral swelling in the labial vestibule on the right side. (c) Straw-colored fluid on aspiration from the right-sided cyst

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Occlusal radiograph [Figure 2]a showed a large scooped-out radiolucent area with 'cupping' surrounding upper left central incisor (UL1) in the middle and coronal thirds of its root, but not in the periapical area. Radiograph was noncontributory on right side. Provisional diagnosis of bilateral nasolabial cysts was made on the basis of above findings. Patient's informed consent was availed for the surgical removal of these cysts. Medical history did not present any contraindication for the surgical procedure.

The cysts were enucleated [Figure 2]b and c using intraoral approach under local anesthesia and adrenaline (1:80,000). A full-thickness incision was reflected along the crest of maxillary alveolar ridge in the canine to canine region and blunt dissection by periosteal elevator exposed two smooth, well-circumscribed cystic swellings just below the nasal floor. There had been scooping of the anterior maxilla on the left side due to expansion of the cyst. In contrast, morphology of alveolar bone on right side was not affected. In the same appointment, extractions of hopeless teeth were also done and the wound was closed with loop sutures using 3-0 non-absorbable black mersilk after debridement and irrigation with normal saline. Postoperative instructions were delivered. Tissue was sent for histopathological confirmation.
Figure 2: (a) Occlusal radiograph showing erosion of bone in a "cupping" fashion. (b) Enucleation of right cyst. (c) Enucleation of left cyst

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Histopathology of the right-sided cyst revealed a cystic cavity lined by variable thickness of epithelium predominantly made up of many layered stratified squamous cells along with a few mucosal cells [Figure 3]. At few places, stratified squamous and pseudostratified columnar epithelia with many cilia and goblet cells were also evident [Figure 4]a and b. Capsule showed loosely arranged fibrous tissue infiltrated with dense diffuse chronic inflammatory infiltrate. Left-sided cyst specimen showed two or more layered stratified squamous lining epithelium with thin capsule [Figure 5]. Diagnosis confirmed the presence of bilateral nasolabial cysts.
Figure 3: Photomicrograph of a section of right cyst showing epithelial lining predominantly made of many layered stratified squamous cells with few mucosal cells (H&E stain, 100)

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Figure 4: (a) Photomicrograph of right cyst: Stratified squamous epithelium with mucous cells and cilia (H&E stain, 400). (b) Photomicrograph of right cyst: Pseudostratified ciliated columnar epithelium with goblet cells (H&E stain, 400)

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Figure 5: Photomicrograph of left cyst showing cystic cavity lined by stratified squamous non-keratinized epithelium with thin capsule (H&E stain, ×40)

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   Discussion Top


Nasolabial cyst may be asymptomatic or cause a swelling in the mucolabial fold. Patients seek medical assistance when the cyst becomes infected or cause a cosmetic defect. [1],[2],[4],[5],[6] In the present case, intraoral swellings were present in the labial vestibule on both sides, lateral to the maxillary central incisors, which is the most common symptom associated with this cyst. [1],[7]

As the nasolabial cysts arise in soft tissues, in most cases there are no radiographic changes. Occasionally, pressure resorption of the underlying bone may occur, in that case, it is known as nasoalveolar cyst, where the cyst being external to the alveolar bone, produces "cupping" of the underlying cortical plate. [4] In the present report, erosion of bone in a "cupping" fashion around UL1 was observed as a sequel of pressure from the cyst.

Routine intraoral radiographs are not diagnostic for nasoalveolar cysts but assist in excluding other odontogenic or non-odontogenic cysts. Periapical inflammatory lesions can be excluded by vitality testing of the associated teeth and the absence of radiolucency in the periapical region on intraoral radiographs. Globulomaxillary and nasopalatine duct cysts can easily be mistaken as nasolabial cysts; however, both of these are intraosseous lesions. [8] In the present case, periapical radiolucency with maxillary anterior teeth was absent. On the contrary, the rarefaction was observed in the middle and coronal third of the root of UL1. Adjacent teeth were vital.

Nasolabial cyst does not cause any displacement of the teeth. However, Cohen and Hertzanu [5] have reported a case of nasolabial cyst with a high growth potential that resulted in the erosion of maxillary alveolus, invaded supporting structures in the region of incisors and caused displacement of these teeth. In the present case also, there were signs of displacement of adjacent teeth. Distolabial migration of the crowns of upper central incisors was primarily due to loss of periodontal support caused by periodontitis in addition to pressure from the cyst.

10.6% of nasolabial cysts are bilateral, this finding suggests that these cysts are developmental in origin. [9] Etiopathogenesis of this cyst involves two theories suggesting that it arises:

  1. As a fissural cyst which develops from embryonic nasal epithelium entrapped between the merging maxillary processes and the medial and lateral nasal processes [10]
  2. As a developmental cyst arising from the remnants of the embryonic nasolacrimal ducts, due to histological similarities to the latter. [11] Furthermore, this cyst is in the area of the naso-optic furrow and proliferation of the nasolacrimal duct has been seen at this site. Although this theory may need some revision, due to the finding of apocrine secretion along the surface of the nasolabial cyst, it seems to be the most accepted one at this stage. [12] The fact that high percentage of linings demonstrate pseudostratified columnar epithelium, [9] often with cilia or numerous goblet cells, is compatible with origin from primitive ductal or glandular structures. So, the most likely origin is from the nasolacrimal duct. [4] In case presented here, the cystic lining was predominantly stratified squamous type, although few areas showed pseudostratified ciliated columnar epithelium. Su et al., [13] in their scanning electron microscopic examination revealed that cilia observed in the light microscope were in fact numerous short globular or irregular microvilli which probably resulted from lack of stimulation by air.


In the present case, bimanual palpation (best method of diagnosing this cyst by placing one finger in the labial sulcus and the other on the nasal floor) [9] revealed soft, fluctuant masses bilaterally. Dimension of the cyst in the soft tissues of the labial sulcus was more (2 × 3 cm) on the right side which also produced an extraoral swelling because this cyst was exclusively an extraosseous one. In contrast, the left-sided cyst measured relatively less (1.5 × 1.5 cm) in the soft tissues with no corresponding extraoral swelling because the cyst was occupying space between the vestibular sulcus and alveolar bone as was evident on surgical exploration.

The preferred method of treatment of this cyst is surgical excision by intraoral sub-labial approach, although care must be exercised to prevent perforation and collapse of the lesion. [7],[9] The surgical outcome of this method is generally successful; however, complications associated with the procedure include facial swelling, gingival numbness, decreased sensation of the teeth, and wound infection. An alternative transnasal approach has been suggested that allows endoscopic marsupialization of the cystic cavity. [14] In the present case, full thickness incision was given on the crest of the ridge instead of sub-labial incision (and a mucoperiosteal flap was reflected with a periosteal elevator to expose the cysts) because the surgical procedure was inclusive of extractions of adjacent mutilated teeth.

So, in the presented case; clinical, radiographic and histological features of the lesions were suggestive of nasolabial cyst on the right side and nasoalveolar cyst (residing on the alveolar surface) on the left side, which were successfully enucleated by a modification of intraoral sublingual surgical approach. In 1-year follow-up, no evidence of complications or recurrence was observed.

 
   References Top

1.el-Din K, el-Hamd AA. Nasolabial cyst: A report of eight cases and a review of the literature. J Laryngol Otol 1999;113:747-9.  Back to cited text no. 1
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2.Kuriloff DB. The nasolabial cyst-nasal hamartoma. Otolaryngol Head Neck Surg 1987;96:268-72.  Back to cited text no. 2
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3.Friedrich RE, Scheuer HA, Assaf AT, Zustin J. Nasolabial cyst: Case report with respect to immunohistochemical findings. In Vivo 2012;26:453-8.  Back to cited text no. 3
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4.Neville BW, Damm DD, White DK. Color atlas of clinical oral pathology, 2 nd ed. Hamilton: BC Decker Inc.; 2003. p. 24.  Back to cited text no. 4
    
5.Cohen MA, Hertanzu Y. Huge growth potential of the nasolabial cyst. Oral Surg Oral Med Oral Pathol 1985;59:441-5.  Back to cited text no. 5
    
6.Roed-Petersen B. Nasolabial cysts. A presentation of five patients with a review of the literature. Br J Oral Surg 1969;7:84-95.  Back to cited text no. 6
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7.Choi JH, Cho JH, Kang HJ, Chae SW, Lee SH, Hwang SJ, et al. Naso-labial cyst: A retrospective analysis of 18 cases. Ear Nose Throat J 2002;81:94-6.  Back to cited text no. 7
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8.Lee J, Christmas PI. Bilateral nasolabial cysts: A case report. N Z Dent J 2009;105:43-6.  Back to cited text no. 8
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9.Shear M, Speight PM. Cysts of the Oral and Maxillofacial Regions, 4 th ed. Oxford: Blackwell Munksgaard; 2007. p. 120-22.  Back to cited text no. 9
    
10.Klestadt WD. Nasal cysts and the facial cleft cyst theory. Ann Otol Rhinol Laryngol 1953;62:84-92.  Back to cited text no. 10
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11.Van Bruggemann A. Cysts as a result of developmental problems in the nasal vestibule. Arch Oto Rhino Laryn 1920;33:103-19.  Back to cited text no. 11
    
12.Lopez-Rios F, Lassaletta-Atienza L, Domingo-Carrasco C, Martinez-Tello FJ. Nasolabial cyst: Report of a case with extensive apocrine change. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:404-6.  Back to cited text no. 12
    
13.Su CY, Huang HT, Liu HY, Huang CC, Chien CY. Scanning electron microscopic study of the nasolabial cyst: Its clinical and embryologic implications. Laryngoscope 2006;116:307-11.  Back to cited text no. 13
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14.Su CY, Chien CY, Hwang CF. A new transnasal approach to endoscopic marsupialization of the nasolabial cyst. Laryngoscope 1999;109:1116-8.  Back to cited text no. 14
[PUBMED]    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]



 

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