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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2013  |  Volume : 17  |  Issue : 3  |  Page : 358-362
Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws

1 Department of Oral Pathology, Faculty of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran
2 Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran
3 Department of Pathology, Imam Reza Hospital, Tabriz, Iran
4 Department of Pharmaceutical Technology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Correspondence Address:
Maryam Kouhsoltani
Faculty of Dentisry, Tabriz University of Medical Sciences, Golgasht Street, Tabriz
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Source of Support: Tabriz University of Medical Sciences., Conflict of Interest: None

DOI: 10.4103/0973-029X.125197

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Aim and Objective: The aim of this study was to investigate the expression of Src protein (an osteoclastic factor) in peripheral and central giant cell granulomas (PGCG and CGCGs) of the jaws and the relationship between the expression of this protein and the clinical behavior of these two lesions. Materials and Methods: Thirty cases of PGCG and 30 cases of CGCG were immunohistochemically stained with Src. A staining-intensity-distribution (SID) score (proportion of stained cells × staining intensity) was used to evaluate immunoreactivity of the protein. Data were analyzed using statistical package for social sciences (SPSS) 17.0. Results: There were no significant differences in the Src expression and the SID score between PGCG and CGCG. Furthermore, Spearman's rank correlation coefficient showed that there was a significant correlation between Src expression and SID score within both PGCG and CGCG (P < 0.001; r = 0.87 and 0.75, respectively). Conclusion: The findings of this study suggest that the multinucleated giant cells share some similarities with osteoclasts and Src protein can be used as a new therapeutic target to inhibit osteoclastic activity. In addition, differences in immunoreactivity of this osteoclastic protein do not reflect different clinical behaviors of PGCG and CGCG.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007