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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2013  |  Volume : 17  |  Issue : 3  |  Page : 334-339
Histomorphometric analysis of vascularity in normal buccal mucosa, leukoplakia, and squamous cell carcinoma of buccal mucosa

1 Department of Oral Pathology, Rajarajeshwari Dental College, Bangalore, India
2 Department of Oral Pathology, PM Nadagouda Memorial Dental College and Hospital, Bagalkot, Karnataka, India
3 Department of Oral Pathology, Nair Dental College, Mumbai, Maharashtra, India
4 Department of Oral Pathology, Kamineni Institute of Dental Sciences, Narketpally, Andhra Pradesh, India
5 Department of Oral Pathology, Krishnadevaraya Dental College, Bangalore, Karnataka, India

Correspondence Address:
Ravi Kumar V Pujari
Department of Oral Pathology, Rajarajeshwari Dental Collage, Bangalore 560 060, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.125178

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Context: Angiogenesis, the process that leads to the formation of new blood vessels, continues to be a topic of major scientific interest. There is an increasing hope that new discoveries will lead to newer therapies that target angiogenesis as a reliable option for disease therapy. Aims: The objective of this study was to assess the role of vascularity, correlation of morphometric aspects of vascularity, investigate its usefulness in the histopathological classification and prognosis in normal buccal mucosa (NBM), leukoplakia and squamous cell carcinoma (SCC) of buccal mucosa. Materials and Methods: The study sample consisted of 15 cases of NBM, 30 cases of leukoplakia, and 30 cases of SCC of buccal mucosa. The 75 archival samples were stained by hemotoxylin and eosin (H and E) and Masson's trichrome (MT). The stained sections were analyzed using image analysis software. Statistical analysis used : Statistical Package for Social Sciences (SPSS) 12.0 statistical software. Results : The combined mean vessel density (MVD) of all the cases in H and E was 0.1112 and for MT it was 0.2150. The difference of MVD between H and E and MT was statistically significant. The mean MVD in SCC (0.3455) for MT was higher than NBM (0.1314) and leukoplakia (0.1263). The mean MVD increased from stage III (0.3563) to IV (0.5312). It also increased from NBM (0.1314) to hyperkeratosis (0.1505) and decreased from grade I (0.3556) to II (0.2795) of oral SCC (OSCC). Conclusions: MVD can be used as an adjunct with other diagnostic modalities. Further studies are needed to standardize baseline levels for different sites and age groups.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007