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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2013  |  Volume : 17  |  Issue : 1  |  Page : 51-56
c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study

1 Department of Oral Pathology, HKES' SN Dental College, Gulbarga, Karnataka, India
2 Department of Oral Pathology, Annoor Dental College, Ernakulam, Kerala, India

Correspondence Address:
Zama Moosvi
Central University of Karnataka, 2nd Floor - Karya Soudha, Gulbarga University Campus, Gulbarga - 585 106, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.110725

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Aim: To investigate the role of c-Myc oncogene in selected odontogenic cysts and tumors. Materials and Methods: Ten cases each of ameloblastoma, adenomatoid odontogenic tumor (AOT), odontogenic keratocyst (OKC), dentigerous cyst, and radicular cyst were selected and primary monoclonal mouse anti-human c-Myc antibody was used in a dilution of 1: 50. Statistical Analysis was performed using Mann Whitney U test. Results: 80% positivity was observed in ameloblastoma, AOT and OKC; 50% positivity in radicular cyst and 20% positivity in dentigerous cyst. Comparison of c-Myc expression between ameloblastoma and AOT did not reveal significant results. Similarly, no statistical significance was observed when results of OKC were compared with ameloblastoma and AOT. In contrast, significant differences were seen on comparison of dentigerous cyst with ameloblastoma and AOT and radicular cyst with AOT. Conclusion: From the above data we conclude that (1) Ameloblastoma and AOT have similar proliferative potential and their biologic behavior cannot possibly be attributed to it. (2) OKC has an intrinsic growth potential which is absent in other cysts and reinforces its classification as keratocystic odontogenic tumor.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
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