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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

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Year : 2013  |  Volume : 17  |  Issue : 1  |  Page : 146-147

Molluscum contagiosum

Department of Oral Pathology, V S Dental College and Hospital, Bangalore, Karnataka, India

Date of Web Publication18-Apr-2013

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.110726

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How to cite this article:
Rao K, Priya N S, Umadevi H S, Smitha T. Molluscum contagiosum. J Oral Maxillofac Pathol 2013;17:146-7

How to cite this URL:
Rao K, Priya N S, Umadevi H S, Smitha T. Molluscum contagiosum. J Oral Maxillofac Pathol [serial online] 2013 [cited 2021 Feb 27];17:146-7. Available from: https://www.jomfp.in/text.asp?2013/17/1/146/110726

   Case Details Top

A 41-year-old male patient reported with a chief complaint of multiple papules of 1 year duration in the paraoral region. Patient was human immunodeficiency virus positive and was on highly active antiretroviral therapy.

Microscopic findings

  • Inverted lobular hyperplasia of epidermis resulting in a cup shaped or crater like nodule [Figure 1] and [Figure 2].
  • Center of the lobule showed altered keratinocytes showing a large intra-cytoplasmic, basophilic viral inclusion called Molluscum bodies or Henderson-Paterson bodies [Figure 3].
  • Few keratinocytes showed eosinophilic cytoplasm with peripherally pushed nuclei giving a signet ring appearance [Figure 4].
Figure 1: Inverted lobular hyperplasia of epidermis (H and E, ×40)

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Figure 2: Cup shaped nodule (H and E, ×40)

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Figure 3: Molluscum bodies (H and E, ×100)

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Figure 4: Henderson-Paterson bodies with Signet ring appearance (H and E, ×400)

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   Discussion Top

Molluscum contagiosum (MC) is caused by a DNA pox virus with an incubation period of 2-7 weeks, characterized by a single/multiple, round/dome shaped, pink waxy papule ranging from 1 mm to 5 mm on face, eyelids, neck, axilla and thigh.

Clinical differentials include Cryptococcosis, Histoplasmosis, Basal cell carcinoma, and Keratoacanthoma.

The histopathological features are characteristic, and the presence of Molluscum bodies is diagnostic. MC virus is an intra-cytoplasmic replicating virus in which infected cells grow in size while internal organelles are dislocated and eventually obliterated by large inclusion bodies.

Inclusion bodies are large and the measure up to 35 microns in diameter. They are the result of a virally induced transformation process. Initially, the small virion particle is formed in the cytoplasm of the epithelial cells above the basal layer. These eosinophilic particles grow in size as they progress towards the granular cell layer, causing compression of the nucleus to the periphery of the infected epithelial cells.

The white curd like material expressed from the lesion can be stained with Toluidine blue/Giemsa stain to demonstrate the inclusion bodies.

   Final Diagnosis Top

Molluscum contagiosum (MC).


  [Figure 1], [Figure 2], [Figure 3], [Figure 4]


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