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| ORIGINAL ARTICLE |
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| Year : 2012 |
Volume
: 16 | Issue : 3 | Page
: 343-348 |
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Immunohistochemical evaluation of mast cells and vascular endothelial proliferation in oral precancerous lesion-leukoplakia
M Sathyakumar1, G Sriram2, TR Saraswathi3, B Sivapathasundharam4
1 Department of Oral and Maxillofacial Pathology, SRM, Kattankulathur Dental College, Tamil Nadu, India, India
2 Faculty of Dental Sciences, National University of Singapore
3 Department of oral and maxillofacial Pathology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India
4 Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College, Chennai, India
Correspondence Address:
M Sathyakumar
Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, Kanchipuram District, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-029X.102481
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Background: Oral leukoplakia is the best-known precursor lesion. Although a morphologic feature of oral epithelial dysplasia is well described, less is known about the pathobiologic changes within the cells and over the cell surfaces for malignant transformation. Aims: The present study is aimed at comparing and correlating the mast cell density (MCD) and micro vascular density (MVD) in Normal Mucosa (NM) and different grades of dysplasia and to analyze their role in disease progression. Materials and Methods: MCD was assessed using anti mast cell tryptase and MVD was assessed immunohistochemically using anti-Factor VIII related von Willibrand factor. Results: The Results of the present study showed an exponential increase in microvessel density as mast cell density increased. Conclusion: The role of mast cells in angiogenesis as it progresses from normal mucosa to dysplasia is in concordance with the study. The number of mast cells and microvessel can be used as indictors of disease progression. |
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