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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2012  |  Volume : 16  |  Issue : 3  |  Page : 338-342
Sister chromatid exchanges in smokers and smokers with alcohol habit


1 Department of Oral and Maxillofacial Pathology, Panineeya Institute of Dental Sciences, Hyderabad, Andhra Pradesh, India
2 Department of Oral and Maxillofacial Pathology, Vishnu Dental College, Hyderabad, Andhra Pradesh, India
3 Department of Oral and Maxillofacial Pathology, Ragas Dental College, Hyderabad, Andhra Pradesh, India

Correspondence Address:
J Vijay Kumar
Department of Oral and Maxillofacial Pathology, Panineeya Mahavidyalaya Institute of Dental Sciences, Road No 5, Kamalanagar, Dilshuknagar, Hyderabad, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.102480

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Aim : Sister chromatid exchange (SCE) test is a sensitive, biomarker of genotoxic substances. The present study was conducted to observe the frequency of SCEs in peripheral blood lymphocytes of 30 males with and without the habit of cigarette smoking and alcohol consumption. Materials and Methods : Subjects for this study were males aged between 25-50 years and were selected from the students, employees and the patients attending the outpatient department of Ragas dental college and Hospital, Chennai. Results: Controls, smokers, and smokers with alcohol habit were divided into two age groups as ≤30 years and ≥30 years. In controls the mean frequency of SCEs/cell in ≤30 years and ≥30 year's age group was 5.80 and 6.05, respectively. In Smokers SCEs/cell in ≤30 years and ≥30 year's age group was 7.7 and 8.8, respectively. In Smokers with alcohol habit SCEs/cell in ≤30 years and ≥30 years age group was 10.1 and 12.8, respectively. Conclusions: In this study, the duration of the smoking habit has shown a positive correlation with the mean SCE frequency. Whereas, frequency of the habit did not show any influence on the SCE levels. In smokers with alcohol habit, both the duration and frequency of their smoking habit has shown a significant effect on the SCE levels suggesting a synergistic effect of alcohol and smoking leading to excessive DNA damage.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007