Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contact Us Login 
An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

  Table of Contents    
Year : 2011  |  Volume : 15  |  Issue : 1  |  Page : 65-68

Peripheral ossifying fibroma

1 Department of Periodontology, Mahatma Gandhi Dental College and Hospital, Jaipur, Rajasthan, India
2 Department of Oral and Maxillo-Facial Pathology, Mahatma Gandhi Dental College and Hospital, Jaipur, Rajasthan, India
3 Rotherham General Hospital, Rotherham, Yorkshire, United Kingdom

Date of Web Publication26-Apr-2011

Correspondence Address:
Mahavir B Mishra
14A, Brij Nikunj, Friends Colony, Lal Kothi, Tonk Road, Jaipur - 302 015, Rajasthan
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.80023

Rights and Permissions



Here, we present a case report of peripheral ossifying fibroma (POF) in an adult lady in her fourth decade of life. This case report comprises the growth that occurred in the mandibular anterior region with displacement of anterior teeth, its satisfactory management and literature review. POF represents a reactive benign lesion of connective tissue and is not the soft tissue counterpart of ossifying fibroma and is also not related anyhow to peripheral odontogenic fibroma. POF in the age of 45 years, arising in the mandibular anterior region, is an occasional entity. Careful clinical examination and histopathology findings should be correlated to conclude the final diagnosis.

Keywords: Fibroblast, osteoid tissue, peripheral cemento-ossifying fibroma, peripheral ossifying fibroma, pyogenic granuloma

How to cite this article:
Mishra MB, Bhishen KA, Mishra S. Peripheral ossifying fibroma. J Oral Maxillofac Pathol 2011;15:65-8

How to cite this URL:
Mishra MB, Bhishen KA, Mishra S. Peripheral ossifying fibroma. J Oral Maxillofac Pathol [serial online] 2011 [cited 2022 Oct 5];15:65-8. Available from: https://www.jomfp.in/text.asp?2011/15/1/65/80023

   Introduction Top

Benign fibrous overgrowths arising from the mucous membrane are termed as fibromas and are frequent growths in the oral cavity.

Many of the fibrous growths originate from underneath the periodontium, similar to peripheral ossifying fibroma (POF). POF is an occasional growth of the anterior region of mandible and accounts for 3.1% of all oral tumors and 9.6% of the gingival lesions. About 60% of these tumors occur in maxilla and more than 50% of all cases of maxillary POF are found in the incisors and canine areas. A female of 45 years of age had growth arising in the mandibular anterior region and it displaced the central, lateral incisors and canine. In this age group and in mandibular anterior quadrant, POF is very occasional and has not so far been reported in the literature.

   Case Report Top

A non-smoker female, aged 45 years, reported with a moderately large growth in the mandibular anterior region. Medical history was insignificant. The patient was from low socioeconomic class. History revealed that a small nodule appeared 5 months ago, which was painless and caused spacing in the lower anterior teeth.

On examination, the patient's lips were incompetent. Lower lip approximation was difficult due to large swelling protruding from the lower gingival region. Oral hygiene was considerably poor, which may be due to poor oral hygiene awareness, since oral hygiene is inversely related to socioeconomic class.

There was a pale pink swelling in the mandibular right central and lateral incisor region. The surface was nodular and irregular, with no ulceration. The growth measured 2.2 × 3.0 cm in size and was extending out from labial gingiva, displacing the central, lateral incisors and canine teeth, and extended lingually. The nodular growth extension in lingual was slightly smaller than that in the labial [Figure 1]. The growth was considerably hard in consistency, sessile and not easily movable.
Figure 1: Female patient aged 45 years with POF in mandibular anterior region, displacing central, lateral and canine teeth

Click here to view

Intraoral periapical radiograph was taken, which revealed erosion of the crest of bone. The possible reason of crestal bone erosion in the area may be long-standing plaque-induced inflammation and constant pressure of the growth. Clinical appearance and consistency was of a hard fibrous growth, which therefore led to a provisional diagnosis of peripheral calcifying fibroma or peripheral odontogenic fibroma (POdF).

Phase 1 periodontal treatment was carried out. Consent for the surgical procedure was obtained from the patient after proper counseling.

Under local anesthesia, the whole growth was excised and the underlying surface was thoroughly curetted up to deepest possible tissue and crestal osteoplasty was done. After controlling bleeding, periodontal dressing was applied and the patient was discharged with prescription of pain killer and chlorhexidine mouth wash. Follow-up visits were arranged after 1 week, followed by 1 month, 3 months, 6 months and 1 year and 2 years. Recall was necessary to rule out recurrence of the lesion, since it eroded alveolar bone and appeared aggressive.

The growth was sent for the histo-pathologic evaluation. The report revealed an over growth of fibrous tissue. The connective tissue of the growth comprised of bundles of collagen fibers in a cellular stroma [Figure 2]. Numerous plumps to spindle shaped fibroblasts and fibrocytes were present. These cells were also arranged in a whirl shaped around irregular mineralization foci in the center [Figure 3]. Few blood vessels with RBC and proliferating endothelial cells were also evident. Chronic inflammatory cell infiltrate was seen evenly distributed in whole area and the cells comprised mainly of lymphocytes and plasma cells [Figure 4]. The calcified areas resembled cementum-like and bone-like ossifying areas [Figure 5].
Figure 2: Microscopic picture of biopsy slide showing- proliferated fibrous bands in the connective tissue with uniformly distributed chronic inflammatory cells

Click here to view
Figure 3: Micro-photograph of another specimen of the same biopsy, showing thick fibrous whirls

Click here to view
Figure 4: Multiple foci of osteoid tissue, surrounded by fibrous whirls

Click here to view
Figure 5: Sam slide at further location showing multiple foci of osteoid tissue, surrounded by fibrous bands

Click here to view

Few blood vessels with RBC and proliferating endothelial cells were also evident. Chronic inflammatory cell infiltrate was seen evenly distributed in the whole area and the cells comprised mainly lymphocytes and plasma cells.

The overlying epithelium was hyperplastic parakeratotic stratified squamous epithelium showing numerous elongated rete ridges. Clinical assessment and histopathologic report confirmed and established the diagnosis as POF.

   Discussion Top

In oral cavity periodontium can show different types of focal overgrowths. These lesions arise due to overgrowth and proliferation of different components of connective tissue in periodontium, i.e. the fibers, bone, cementum, blood vessel or any particular type of cell. The lexicon of focal proliferative lesions commonly occurring on gingival tissue includes fibroma, giant cell fibroma, pyogenic granuloma, peripheral giant cell granuloma, POF and POdF. [1] Most of these lesions are reactive chronic inflammatory hyperplasias, with minor trauma or chronic irritation being the etiologic factors. [2]

The nomenclature of these lesions is done in such a way so as to highlight the difference in nature of growth, location of growth, origin and the dominant proliferating histological component/cells in the lesion. The lesions which are present intraosseously are termed as "central lesions", whereas their extraosseous counterparts or the lesions which appear on outer soft tissue (e.g. gingiva) are termed "peripheral lesions". Also, a lesion may arise due to inflammation because of a stimulus and is called as a "reactive lesion" or it can be truly "neoplastic" where it is classified as a benign or a malignant neoplasm.

The term POF was coined by Eversole and Robin. [3] It occurs exclusively on gingiva. It is a relatively common growth of gingiva and is considered to be reactive in nature rather than neoplastic. [4] POF is characterized by a high degree of cellularity usually exhibiting bone formation, although occasionally, cementum-like material or dystrophic calcification may also be found. [1]

As the lesion occurs only on gingiva and is supposed to be derived from periodontal ligaments, some authorities believed the lesion to be odontogenic in origin. [1]

Presently, the origin and pathogenesis of the lesion is unknown. However, due to their clinical and histopathologic similarity, it is considered that at least some cases of POF may arise as a result of maturation of a long-standing pyogenic granuloma. [4]

The mineralized product in POF probably has its origin from cells of periosteum or periodontal ligament. [5]

The POF has a peak incidence in young and teenaged females. [4] Cundiff reported that the lesion is prevalent between ages of 5 and 25 years, with a peak incidence at 13 years of age. Cundiff also reported a definite female predilection. [6] Female to male ratio may vary from 2:1 to 3:2. The site of occurrence of POF is usually anterior to molars in both maxilla and mandible equally, [1] and in more than 50% of cases in the incisor, and cuspid regions. [5]

Clinically, the lesion appears as a nodular mass which may be pedunculated or sessile, pink to red in color and surface is usually but not always ulcerated. In the present case also, the lesion occurred in a middle-aged female in mandibular anterior region and appeared as a nodular pale to pink growth without ulceration.

Histopathologically, the lesion shows stratified squamous epithelium covering an exceedingly cellular mass of connective tissue made up of plump fibroblasts, fibrocytes, fibrillar stroma and areas of mineralization with multinucleated giant cells near them in some cases. The mineralization may consist of bone, cementum-like material or dystrophic calcifications. The dystrophic calcifications are usually seen in early, ulcerated lesions, whereas the older, mature, non-ulcerated lesions show well-formed bone and cementum-like material, [5] as was evident in the present case also.

The clinical differential diagnosis of POF includes all the nodular lesions which occur on gingiva (as mentioned before). Histopathologically, it is very important to understand the difference between the similar sounding lesions, i.e. POF, POdF, central ossifying fibroma (COF) and central odontogenic fibroma (COdF).

Despite of similarity in terminology, POF is a completely distinct entity from POdF and COF. The POF, representing a reactive benign lesion of connective tissue, is not the soft tissue counterpart (or related anyhow) to central ossifying fibroma which represents an osteogenic neoplasm. [5]

Similarly, the reactive lesion POF is completely different from POdF which is in fact a neoplasm of odontogenic ectomesenchyme with included odontogenic epithelium. As opposite to POF and COF, the POdF does represent the extraosseous counterpart of the COdF and is related to it [Table 1].
Table 1: The important differences between POF, COF, POdF and COdF

Click here to view

   Conclusion Top

The POF represents a reactive benign lesion of connective tissue and is not the soft tissue counterpart of ossifying fibroma (COF) and is also not related anyhow to POdF. It occurs frequently in anterior part of jaws of young females, exclusively on gingiva. The accepted treatment protocol includes surgical excision followed by histopathologic evaluation and follow-up.

   References Top

1.Rajendran R, Sivapathasundharam B. Shafers's textbook of oral pathology. 6 th ed. Noida, India: Elsevier; 2009. p. 128.  Back to cited text no. 1
2.Vaishali K, Raghavendra B, Nishit S. Peripheral ossifying fibroma. J Indian Acad Oral Med Pathol 2008;20:54-6.  Back to cited text no. 2
3.Eversole LR, Robin S. Reactive lesions of gingiva. J Oral Pathol 1972;1:30-8.  Back to cited text no. 3
4.Fausto KA. Robbins and Cotran pathologic basis of disease. 7 th ed. Philadelphia: WB Saunders; 2008. p. 775-6.   Back to cited text no. 4
5.Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 2 nd ed. New Delhi: Elsevier; 2005. p. 563-4.   Back to cited text no. 5
6.Cundiff EJ. Peripheral ossifying fibroma: A review of 365 cases. USA: MSD Thesis Indiana University; 1972.  Back to cited text no. 6


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]

  [Table 1]

This article has been cited by
1 Immunohistochemical Evaluation of IL-1ß, IL-6, TNF-a and IL-17 Cytokine Expression in Peripheral Giant Cell Granuloma and Peripheral Ossifying Fibroma of the Jaws
Ömer Ekici, Sinan Ay, Mustafa Fuat Açikalin, Özgül Pasaoglu
Archives of Oral Biology. 2022; : 105385
[Pubmed] | [DOI]
2 Multifaceted presentation of peripheral ossifying fibroma: Case series spanning three age groups
Ambili Gopalakrishnan, Baiju Radhamoni Madhavanpillai, Binitta Paul Kannappillil, Jithin Balan
IP International Journal of Periodontology and Implantology. 2022; 7(3): 136
[Pubmed] | [DOI]
3 Juvenile trabecular ossifying fibroma of the maxilla: Case report of a diagnostic dilemma
HassanMir Mohammad Sadeghi, ZahraSadat Torabi, Hamidreza Moslemi, Shervin Shafiei, SanazGholami Toghchi, Fatemeh Mashhadiabbas
Dental Research Journal. 2021; 18(1): 102
[Pubmed] | [DOI]
4 Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report
Naina Pattnaik, JagadishP Rajguru, SamarjeetJ Pattanaik, Debajyoti Bardhan, Bikash Nayak, Md MustaqFizur Islam
Journal of Family Medicine and Primary Care. 2020; 9(6): 3142
[Pubmed] | [DOI]
5 Peripheral ossifying fibroma- A case report with brief review
Banushree C S, Dharanya M, Ramachandra V Bhat, Devakumari S
Indian Journal of Pathology and Oncology. 2020; 7(3): 474
[Pubmed] | [DOI]
6 Diode laser for excisional biopsy of a peripheral ossifying fibroma: A case report
Emmanouil Vlachos, Despina Gkouzoula, Ioannis Fourmousis
Journal of Dental Problems and Solutions. 2020; : 096
[Pubmed] | [DOI]
7 Peripheral ossifying fibroma of the anterior maxillary gingiva
Ganendra Anugraha, Ni Putu Mira Sumarta
Dental Journal (Majalah Kedokteran Gigi). 2019; 52(4): 204
[Pubmed] | [DOI]
8 A Rare Case Report of Coexistence of Peripheral Ossifying Fibroma with Fibrolipoma
Ambika S Arora, Deepa Das, Priyanka Tidke
Journal of Contemporary Dentistry. 2018; 8(1): 57
[Pubmed] | [DOI]
9 Peripheral Ossifying Fibroma in Rare Site: A Clinicopathological Report
Nagaraj Kalburgi, Apoorva Kamat, Jane Mary, Ankita Kotecha
Journal of Health Sciences & Research. 2015; 6(2): 60
[Pubmed] | [DOI]
10 The varying clinical presentations of peripheral ossifying fibroma: A report of three cases
Pal, S. and Hegde, S. and Ajila, V.
Revista Odonto Ciencia. 2012; 27(3): 251-255


Print this article  Email this article


    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Article in PDF (2,075 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

    Case Report
    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded823    
    Comments [Add]    
    Cited by others 10    

Recommend this journal

© Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007