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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
KNOW THIS FIELD Table of Contents   
Year : 2009  |  Volume : 13  |  Issue : 1  |  Page : 9
 

Know this field


Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College and Hospital, Chennai, India

Correspondence Address:
Shweta Nag
Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College and Hospital, Chennai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.48875

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How to cite this article:
Nag S, Manjunath K, Sriram G, Sivapathasundharam B. Know this field. J Oral Maxillofac Pathol 2009;13:9

How to cite this URL:
Nag S, Manjunath K, Sriram G, Sivapathasundharam B. Know this field. J Oral Maxillofac Pathol [serial online] 2009 [cited 2021 Aug 1];13:9. Available from: https://www.jomfp.in/text.asp?2009/13/1/9/48875



   Case Details Top


A 55-year-old female reported with burning sensation, reddish upper and lower gingiva and vesicles in the palate and buccal mucosa.


   Histopathology Top


  • Stratified squamous epithelium separated from the underlying connective tissue.
  • The separation of the epithelium from the connective tissue is seen below the basal layer.
  • The roof of the split is made up of basal cells and the floor consists of the connective tissue.
  • The split (vesicle/ bulla) consists of clear fluid or red blood cells. No acantholytic cells are evident in the vesicular space.
  • Connective tissue shows diffuse chronic inflammatory cell infiltrate.



   Differential Diagnosis Top


Pemphigus vulgaris shows a suprabasilar cleavage with the basal cells placed in the floor of the vesicle and the vesicular space usually contains acantholytic cells.

Dermatitis herpetiformis also shows a sub-basilar split but is characterized by a subepidermal infiltrate of neutrophils with papillary microabscess.

Epidermolysis bullosa (junctional, dystrophic and hemidesmosomal forms) show a subepithelial clefting. But this disorder is transmitted in autosomal or recessive manner and manifests at an early age.

Linear IgA bullous dermatitis shows subepithelial cleavage and linear deposits of IgA along the basement membrane zone and predominantly affects the skin.

Angina bullosa hemorrhagica exhibits blood-filled subepithelial vesicles or bullae usually affecting the soft palate of middle-aged or older adults.

Lichen planus pemphigoides shows subepithelial bulla with an infiltrate that is diffuse and that contains eosinophils.

Lichen planus may occasionally show areas of sub-basilar cleavage similar to that in pemhigoid. This separation is an artifact attributed to basal cell degeneration and are called as Max-Joseph spaces.


   Final Diagnosis Top


Mucous Membrane Pemphigoid[Figure 1],[Figure 2],[Figure 3],[Figure 4],[Figure 5],[Figure 6],[Figure 7],[Figure 8],[Figure 9]


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9]



 

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
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