KNOW THIS FIELD
|Year : 2009 | Volume
| Issue : 1 | Page : 9
Know this field
Shweta Nag, K Manjunath, G Sriram, B Sivapathasundharam
Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College and Hospital, Chennai, India
Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College and Hospital, Chennai
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Nag S, Manjunath K, Sriram G, Sivapathasundharam B. Know this field. J Oral Maxillofac Pathol 2009;13:9
| Case Details|| |
A 55-year-old female reported with burning sensation, reddish upper and lower gingiva and vesicles in the palate and buccal mucosa.
| Histopathology|| |
- Stratified squamous epithelium separated from the underlying connective tissue.
- The separation of the epithelium from the connective tissue is seen below the basal layer.
- The roof of the split is made up of basal cells and the floor consists of the connective tissue.
- The split (vesicle/ bulla) consists of clear fluid or red blood cells. No acantholytic cells are evident in the vesicular space.
- Connective tissue shows diffuse chronic inflammatory cell infiltrate.
| Differential Diagnosis|| |
Pemphigus vulgaris shows a suprabasilar cleavage with the basal cells placed in the floor of the vesicle and the vesicular space usually contains acantholytic cells.
Dermatitis herpetiformis also shows a sub-basilar split but is characterized by a subepidermal infiltrate of neutrophils with papillary microabscess.
Epidermolysis bullosa (junctional, dystrophic and hemidesmosomal forms) show a subepithelial clefting. But this disorder is transmitted in autosomal or recessive manner and manifests at an early age.
Linear IgA bullous dermatitis shows subepithelial cleavage and linear deposits of IgA along the basement membrane zone and predominantly affects the skin.
Angina bullosa hemorrhagica exhibits blood-filled subepithelial vesicles or bullae usually affecting the soft palate of middle-aged or older adults.
Lichen planus pemphigoides shows subepithelial bulla with an infiltrate that is diffuse and that contains eosinophils.
Lichen planus may occasionally show areas of sub-basilar cleavage similar to that in pemhigoid. This separation is an artifact attributed to basal cell degeneration and are called as Max-Joseph spaces.
| Final Diagnosis|| |
Mucous Membrane Pemphigoid[Figure 1],[Figure 2],[Figure 3],[Figure 4],[Figure 5],[Figure 6],[Figure 7],[Figure 8],[Figure 9]
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9]