REVIEW OF SCIENTIFIC ARTICLES
|Year : 2004 | Volume
| Issue : 2 | Page : 110-111
Review of scientific articles
Department of Oral and Maxillo Facial Pathology, Meenakshi Ammal Dental College and Hospital, Chennai, India
Department of Oral and Maxillo Facial Pathology, Meenakshi Ammal Dental College and Hospital, Chennai
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Lavanya S. Review of scientific articles. J Oral Maxillofac Pathol 2004;8:110-1
Are tumors angiogenesis dependent?
J PATHOLOGY 2004.202. 5-13
Many invitro and invivo studies showed that tumour growth requires expansion of vasculature. If that is the case, then by inducing angiogencsis inhibitors, one can prevent the tumor growth and mans annual studies proved this statement. But this has not been applied friutfully in clinical studies: the reasons for this is yet to be answered.
The author in this review explained the possible reasons for the failure of successful clinical approach in tumor suppression by angiogenests inhibitors. The compared the invivo and invitro studies and discussed about the regulators of angiogenesis. the angiogenic switch, the mechanism by which dormant tumors become angiogenic, clinical studies, indicating the importance of angiogenesis in tumor growth, clinical anti-angiogenic studies the conclusion of this article, that human tumors are heterogenous in their vascular architecture and function. Tumor induced angiogenesis in humans is amore complex process than angiogenesis in preclinical cancer models and angiogenesis is not the only factor that determines tumor growth, the other factors include genetic changes and biochemical pathways. So, the treatment strategic, with biological scents that interfere different hallmarks of tumor growth must be developed for proper tumor suppression.
Tumour associated tissue eosinophiIia as a prognostic factor in oral squamous cell carcinomas
HISTOPATHOLOGY 2002.41: 152-157
Eosinophils are one of the inflammatory cells and their granules contain cationic proteins such as major basic protein, eosinophil cationic protein, eosinophil derived neurotoxin, and eosinophil peroxidase. The exact role of eosinophils is tumours is yet to lie identified hill thought to be related to good to poor prognosis or even having no influence on patient's outcomes Many authors suggested that cosinophils could play a protective role against tumour progresion by different mechanisms. It varies from the capacity of eosinophils to perfunn antibody dependent cell mediated cylotoxicity to its capacity of synthesize and release cationic proteins known to have cytotoxic properties as well as cytokines such as II-I, IL-3, TNFalfa TGF-beta that could contribute to tumor cytotoxicity directly acting against tumour cells or indirectly through the autocrine activation of eosinophils or even stimulating additional effector cells.Tumor associated tissue eosinophiIia is characterized by the presence of' cosinophils as a component of peri and intro lunioral inflammatory infiltrate.
The author studied 125 oral squamous cell carcinoma patients to evaluate the influence of tumor associate tissue eosrinipliilia on its prognosis. The number of eosinophils was obtained by morphometric analysis and ranged from 0 to 392 per cu. mitt .Tumour associated tissue eosinophiIia as classified according to the intensity annual moderate or intense the intensity of mono nuclear inflammatory infiltrate and the location of eosinophil inflammatory infiltrate was statistically correlated, and concluded that intense tumor associated tissue eosinophiIia is an independent favorable prognostic factor for oral squamous cell carcinomas.
Immunohistochemistry in the diagnosis of soft tissue tumours
J OF HISTOPATHOLOGY 2003. 43: 1-16
Immunohistochemistry is a technique for identify in cellular or tissue constituents (antigens) by means of antigen-antibody interactions, laheluig the antigenic site cithci directly/indirectly by the useol'secondarv labeling.
Immunohistochemistry has three uses. to identify sonic rare or atypical benign lesions to characterize non mesenchymal tumors and to classify sarcomas. The future of immunohistochemistry is promising with the new developments in micro array technology that will select new useful proteins for diagnosis, prognosis and treatment decision making. Immunohistochemistry is particularly important in the diagnosis of soil tissue motors because of their several lines of differentiation and frequent dituiculty in diagnosis.
This review discusses the practical aspects of the diagnosis of soft tissue tumors on fixed and paraffin embedded tissues w ith the use of commercially at adable antibodies. The author mentioned shout various new antibodies such as Myogen. CD117, H-Calderman. Human herpes virus type 8 (HHV8), Mdm 2, Bel 2, Wilms tumour suppresser gene product(WTI) and their clinical significance in diagnosing the various soft tissue tumour along with their draw hacks.
Oral manifestations of primary immunological diseases
JADA 2000. VOL 131
The body's defence mechanism mainly depends on the elective functioning entire immune system. Any immune defect increases the susceptibility of the body to infections. Primary disorders of the immune system are caused when defective genes controlling the development and maturation of immune cells are expressed. Immune deficiences arc expressed variously and most noticeable oral manifestations of primary immune deficiencies are
The author in this article described in detail about the immune system and various oral manifestations of the primary immunodefieiencies and the line of treatment. These diseases are categuriied according to the missing or dysfunctional cell types into deficeincies of T cells. B cells. Phagocytes Combined deficiency of T and B Cells defects leads to all types of infections and oral manifestation., include candidiasis, Herpes infections,Oral infections severe necrotising gingival stomatosis.Tcell. deficiency leads to viral, fungal. parasitic infection.and oral manifestations include candidiasis. Ludwig's angina. Oral ulcerations. B cell defects increases the bacterial susceptibility and oral manifestations Include septicemia: from uduntuuenic infections, candidiasis, oral ulecrationsNcutrophil defects include recurrent infections wish , staphylococci,pseudo nonas,candida,fungi and recurrent pyogcnic infections with extracellular bacteria is also seen.
Expression of MMP l, MMP 2, MMP 9, in carcinoma of the head and neck. Correlation with p53 status, inducible nitric oxide synthase activity and angiogenesis
CANCER 2002, Vol 95: No. 9
Tumour growth mainly depends on the angiogcnesis and invasion of surrounding tissues. Fire process of invasion and spread to distant sites requires the expression and activation of proteolytic enrynles that are involved in the degradation of extra-cellular main is molecules to a:low the migration of nimor cells. Matrix metalloproteinase. (MMP's) are a family of secreted or transinenibra ne proteins that arc capable of digesting extracellular matrix and basement membrane components. Some authors found the relation between the MM Ps, Nitric oxide INO), abnormalitics of p53gene and tumour invasion in head and neck carcinomas.
In this article, the author reported a study done to find the relationship between the expression of matrix metalloproteins in head and neck carcinomas with the other steps involved in the tumor growth and metastatis like angiogenesis, activation of Nitric oxide (NO) pathway and alteration of p53 tumor suppressor gene. Study sample consists of 43 patients with Head and Neck squantous cell carcinomas and expression levels of MMI'-1. MMp-2", And MMP-9 were examined immunohistochemically. Microvessel density (MV D) of the endothelial cells with anti-CD31 monoclonal antibody was determined by inmtunostaining. Inducible Nitric oxide synthase activity and cyclic guanosine nionophosphate levels were assessed in the fresh tumor samples. whereas exons 5-9 of p53 gene were analyzed by reverse transcriptase polynterase chain reaction. single-strand confirmation polymorllhism and were sequenced.
With the results obtained, he concluded that there is a strong correlation between MMP expression activity of NOs pathway. p53 Status and angiogenesis in HNSCC. This study suggests that p53 tumor supressor gene may regulate the expression ofNOS, MMPs and angiogcnesis and thus p53 mutation which is present frequently in patients with HNSCC may result in increased angiogcnesis and invasiveness related to the increased NO and MMP production by tumor cells leading to rumor progression.
Integrins in regulation of tissue development and function
J OF PATHOLOGY 2003. 20C:471-480
Integrins are adhesion receptors found in metazoans ranging front sponges to worms, flies and mammals. These are the heterodimeric transmenbrane receptors that bind to components of the extracellular matrix They mediate stable adhesion as well as migration and modulate virtually even intracelIular signaling cascade.
The importance of integrins lies in their adhesive function as well as in their capacity to modulate signal transduction pathways downstream of other receptors Integrins mediated adhesion cut modulate many different siunel Irauducliun cascades and support cell survival. proliferation and influence the expression of differentiation- related genes.
This article discusses how the integrins can affect the multitude of signal transduction cascades. The author describes the role of integrins like Beta and its subtypes in the developument of basement membrane, epidermal cells of skin, endothelial cells of blood vessels, development of bone, maintainence of skeletal muscle development and functions of immune system in detail.