Journal of Oral and Maxillofacial Pathology

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 23  |  Issue : 3  |  Page : 369--377

Tumor necrosis factor-like weak inducer of apoptosis expression in healthy oral mucosa, oral dysplasia and oral squamous cell carcinoma


Swetha Acharya1, Prashant Prabhu1, Vidya Patil2, Anirudh B Acharya3, Anil Desai4, Krithi Nikhil5 
1 Department of Oral Pathology and Microbiology, SDM College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheswara University, Dharwad, Karnataka, India
2 Department of Biochemistry, SDM College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheswara University, Dharwad, Karnataka, India
3 Department of Periodontics, College of Dentistry, Majmaah University, Zulfi, Kingdom of Saudi Arabia
4 Department of Oral and Maxillofacial Surgery, SDM College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheswara University, Dharwad, Karnataka, India
5 Consultant, Biostatistician, Dharwad, Karnataka, India

Correspondence Address:
Swetha Acharya
Department of Oral Pathology and Microbiology, SDM College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheswara University, Dharwad - 580 009, Karnataka
India

Objective: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has been implicated in the pathogenesis of cancer, as it participates in the progression of internal malignancies. However, its role in the biology of squamous cell carcinoma (SCC) is uncertain. Studies regarding TWEAK in SCC have shown inconsistent results. We aimed to study the expression of TWEAK in healthy oral mucosa, oral dysplastic lesions and in oral SCC (OSCC). Methods: Immunohistochemistry for TWEAK was performed on one hundred oral mucosal tissues, healthy control (HC) (n = 20), oral dysplasia (OD) (n = 20) and OSCC (n = 60). Staining intensity, extent of staining (ES) and immunoreactive Score (IRS) were assessed for each sample. Kruskal–Wallis ANOVA, Mann–Whitney U, Chi-square and Spearman's rank correlation coefficient were applied. Results: TWEAK was expressed in 55% of HC, 90% of OD and in all cases of OSCC, with variable intensities. A significant difference in the ES and IRS of TWEAK was noted among the three groups. ES and IRS were highest in OSCC group. ES of TWEAK was significantly higher at invasive tumor front (ITF) than in the whole tumor, with a significant positive correlation. TWEAK expression showed a significant association with invasive front grading, pattern of invasion and surgical margins of OSCC. Conclusions: TWEAK may contribute to the progression of OSCC. It might also sustain altered differentiation, invasion and migration of tumor cells at ITF.


How to cite this article:
Acharya S, Prabhu P, Patil V, Acharya AB, Desai A, Nikhil K. Tumor necrosis factor-like weak inducer of apoptosis expression in healthy oral mucosa, oral dysplasia and oral squamous cell carcinoma.J Oral Maxillofac Pathol 2019;23:369-377


How to cite this URL:
Acharya S, Prabhu P, Patil V, Acharya AB, Desai A, Nikhil K. Tumor necrosis factor-like weak inducer of apoptosis expression in healthy oral mucosa, oral dysplasia and oral squamous cell carcinoma. J Oral Maxillofac Pathol [serial online] 2019 [cited 2020 Sep 18 ];23:369-377
Available from: http://www.jomfp.in/article.asp?issn=0973-029X;year=2019;volume=23;issue=3;spage=369;epage=377;aulast=Acharya;type=0