Journal of Oral and Maxillofacial Pathology

INVITED REVIEW
Year
: 2019  |  Volume : 23  |  Issue : 3  |  Page : 318--323

Tumor budding is a potential histopathological marker in the prognosis of oral squamous cell carcinoma: Current status and future prospects


Alka D Kale, Punnya V Angadi 
 Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research, Belgaum, Karnataka, India

Correspondence Address:
Punnya V Angadi
Department of Oral Pathology and Medicine, KLEVK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research, Belgaum - 590 010, Karnataka
India

Tumor budding (TB) is a histopathologically evident feature that represents a scattered pattern of invasion consisting of isolated single tumor epithelial cells or tumor cells in small clusters (up to 5 cells) seen primarily at the invasive front dispersed within the stroma for variable distance. Presence of TB has been linked with lymph node metastasis, recurrence, distant metastasis and reduced survival in numerous cancers including oral squamous cell carcinoma (OSCC). Tumor buds are also considered as histopathological markers of epithelial–mesenchymal transition which is a molecular process implicated as a hallmark for invasion and metastasis. This review gives an overview of the current evidence regarding TB assessment in OSCC and its future prospects.


How to cite this article:
Kale AD, Angadi PV. Tumor budding is a potential histopathological marker in the prognosis of oral squamous cell carcinoma: Current status and future prospects.J Oral Maxillofac Pathol 2019;23:318-323


How to cite this URL:
Kale AD, Angadi PV. Tumor budding is a potential histopathological marker in the prognosis of oral squamous cell carcinoma: Current status and future prospects. J Oral Maxillofac Pathol [serial online] 2019 [cited 2020 Jan 18 ];23:318-323
Available from: http://www.jomfp.in/article.asp?issn=0973-029X;year=2019;volume=23;issue=3;spage=318;epage=323;aulast=Kale;type=0