Year : 2018 | Volume
: 22 | Issue : 2 | Page : 210--215
Expression of mucin-1 in oral squamous cell carcinoma and normal oral mucosa: An immunohistochemical study
Arush Thakur1, Jagdish V Tupkari1, Tabita Joy1, Prajwalit Prakash Kende2, Pooja Siwach1, Manisha S Ahire1
1 Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai, Maharashtra, India
2 Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, Mumbai, Maharashtra, India
Background: Mucins are high-molecular-weight glycoproteins with a high O-linked carbohydrate content, which are synthesized by many secretory epithelial cells as membrane-bound and/or secreted products. Mucin-1 (MUC1) is a transmembrane mucin that protects and lubricates the mucous membranes of the human body and involves itself in various cellular functions such as growth, differentiation and signaling. An aberrant expression of MUC1 has been demonstrated in various human cancers. Many studies on MUC1 expression have been conducted on a variety of neoplastic lesions other than head-and-neck region. In this study, an attempt has been made to evaluate the MUC1 immunoexpression in oral squamous cell carcinoma (OSCC) and normal oral mucosa (NOM).
Aims: This study aims to compare and correlate the immunoexpression of MUC1 in NOM and OSCC using immunohistochemical technique.
Settings and Design: Thirty patients of OSCC formed the study group and thirty patients were included in the control group (NOM). Formalin-fixed paraffin wax blocks were prepared from the tissue samples obtained.
Materials and Methods: Immunohistochemistry (IHC) for MUC1 was performed, and the overall percentage of positive cells along with distribution and localization of immunoexpression was studied.
Statistical Analysis: Pearson's Chi-square test was used. P <0.05 was considered to be statistically significant.
Results: In OSCC study group, MUC1-positive immunoreaction was observed in 21 (70%) cases out of 30. All the samples in control group were negative for MUC1 immunoexpression. The immunohistochemical expression of MUC1 in OSCC group was statistically significant when compared with normal control group, as P < 0.05 (Pearson's Chi-square).
Conclusions: MUC1 is a reliable biomarker for the diagnosis of OSCC, but further studies are required to prove its role in prognosis.
Department of Oral Pathology and Microbiology, Government Dental College and Hospital, St. George Campus, Near CST Station, Mumbai - 400 001, Maharashtra
|How to cite this article:|
Thakur A, Tupkari JV, Joy T, Kende PP, Siwach P, Ahire MS. Expression of mucin-1 in oral squamous cell carcinoma and normal oral mucosa: An immunohistochemical study.J Oral Maxillofac Pathol 2018;22:210-215
|How to cite this URL:|
Thakur A, Tupkari JV, Joy T, Kende PP, Siwach P, Ahire MS. Expression of mucin-1 in oral squamous cell carcinoma and normal oral mucosa: An immunohistochemical study. J Oral Maxillofac Pathol [serial online] 2018 [cited 2020 Mar 30 ];22:210-215
Available from: http://www.jomfp.in/article.asp?issn=0973-029X;year=2018;volume=22;issue=2;spage=210;epage=215;aulast=Thakur;type=0