Journal of Oral and Maxillofacial Pathology

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 21  |  Issue : 1  |  Page : 18--23

Immunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium


Thara Aravind1, Mahija Janardhanan1, S Rakesh1, Vindhya Savithri1, UG Unnikrishnan2 
1 Department of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India
2 Department of Biostatistics, Amrita School of Dentistry, AIMS, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India

Correspondence Address:
Mahija Janardhanan
Department of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS, Amrita Vishwa Vidyapeetham, Kochi - 682 041, Kerala
India

Background: Early detection of oral squamous cell carcinoma (OSCC) remains one of the most efficient ways to ensure patient survival and improved quality of life. Although specific biomarkers related to OSCC have been investigated, a useful biomarker that assesses the transition potential of potentially malignant lesion to OSCC remains to be found. Osteopontin (OPN) has been recognized as an important factor in tumorigenesis and their expression in OSCC have been investigated earlier. In the present study, evaluation of OPN expression in premalignant and malignant lesions has been carried out to assess their possible role as a biomarker in the early diagnosis and prognosis of OSCC. Objectives: The objective of this study is to evaluate the role of OPN as a biomarker in the diagnosis and prognosis of OSCC. Materials and Methods: The study group consisted of archival paraffin-embedded blocks of ten cases each of varying grades of OSCC, oral epithelial dysplasias and epithelial hyperplasias. Sections were subjected to immunohistochemical staining for the biomarker OPN. Results: A positive OPN expression was noticed in epithelial dysplasias and SCC arising from the oral epithelium. A progressive increase in the intensity of staining was seen with increasing grades of dysplasias and a decrease in OPN expression with an increase in grades was observed in OSCC. Conclusion: The expression of OPN in full thickness of epithelium in severe dysplasias, carcinoma in situ, and in the superficial epithelium of OSCC suggest the possibility of considering OPN expression in full epithelial thickness in dysplasias as an indicator for malignant transformation.


How to cite this article:
Aravind T, Janardhanan M, Rakesh S, Savithri V, Unnikrishnan U G. Immunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium.J Oral Maxillofac Pathol 2017;21:18-23


How to cite this URL:
Aravind T, Janardhanan M, Rakesh S, Savithri V, Unnikrishnan U G. Immunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium. J Oral Maxillofac Pathol [serial online] 2017 [cited 2017 Dec 15 ];21:18-23
Available from: http://www.jomfp.in/article.asp?issn=0973-029X;year=2017;volume=21;issue=1;spage=18;epage=23;aulast=Aravind;type=0