Journal of Oral and Maxillofacial Pathology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 18  |  Issue : 2  |  Page : 211--216

Relationship among tobacco habits, human papilloma virus (HPV) infection, p53 polymorphism/mutation and the risk of oral squamous cell carcinoma


Bidyut Chakrobarty1, Jay Gopal Roy2, Sumit Majumdar3, Divya Uppala3 
1 Department of Oral Pathology, Burdwan Dental College, Burdwan, India
2 Department of Oral Pathology, Dr. R. Ahmed Dental College, Kolkata, West Bengal, India
3 Department of Oral Pathology, Gandhi Institute of Technology and Management Dental College, Visakhapatnam, Andhra Pradesh, India

Correspondence Address:
Divya Uppala
S5, Meher Apartment, CBM Compound, VIP Road, Visakhapatnam 530 003, Andhra Pradesh
India

The prevalence of oral squamous cell carcinoma (OSCC) has significantly increased over decades in several countries and human papilloma virus (HPV) has been indicated as one of the underlying causes. This suggests that HPV plays a role in the early stages of carcinogenesis but is not a requisite for the maintenance and progression of malignant state. p53 is a tumor suppressor gene that checks the cell and promotes apoptosis and cell repair that can be deactivated by mutations and a viral interaction leading to cancer and individuals with particular polymorphic variant of p53 is more susceptible to HPV-induced carcinogenesis. The present study has been carried out to detect and correlate p53 polymorphism/mutation, HPV DNA in the biopsy samples of oral cancer patients who had tobacco habits.


How to cite this article:
Chakrobarty B, Roy JG, Majumdar S, Uppala D. Relationship among tobacco habits, human papilloma virus (HPV) infection, p53 polymorphism/mutation and the risk of oral squamous cell carcinoma.J Oral Maxillofac Pathol 2014;18:211-216


How to cite this URL:
Chakrobarty B, Roy JG, Majumdar S, Uppala D. Relationship among tobacco habits, human papilloma virus (HPV) infection, p53 polymorphism/mutation and the risk of oral squamous cell carcinoma. J Oral Maxillofac Pathol [serial online] 2014 [cited 2020 Aug 13 ];18:211-216
Available from: http://www.jomfp.in/article.asp?issn=0973-029X;year=2014;volume=18;issue=2;spage=211;epage=216;aulast=Chakrobarty;type=0