Journal of Oral and Maxillofacial Pathology

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Year
: 2012  |  Volume : 16  |  Issue : 2  |  Page : 306--307

Undifferentiated pleomorphic sarcoma


Jeyanthi Premkumar, Sathyakumar Mayilvakanam, Yakob Martin, Karupur Thiagarajan Magesh 
 Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, SRM University, Potheri, Kanchipuram Dt, Tamilnadu, India

Correspondence Address:
Jeyanthi Premkumar
Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, SRM University, Potheri, Kanchipuram Dt, Tamilnadu
India




How to cite this article:
Premkumar J, Mayilvakanam S, Martin Y, Magesh KT. Undifferentiated pleomorphic sarcoma.J Oral Maxillofac Pathol 2012;16:306-307


How to cite this URL:
Premkumar J, Mayilvakanam S, Martin Y, Magesh KT. Undifferentiated pleomorphic sarcoma. J Oral Maxillofac Pathol [serial online] 2012 [cited 2020 Aug 3 ];16:306-307
Available from: http://www.jomfp.in/text.asp?2012/16/2/306/99098


Full Text

 Clinical Features



A 42-year-old female patient presented a painless, firm mass on the hard palate involving the premaxilla region. The swelling was small in size initially which grew progressively to a size of 2 × 3 cm in a duration of 3 months.

 Histopathology





The section showed orthokeratinized stratified squamous epithelium in association with connective tissue exhibiting aggregates of spindle-shaped fibroblast-like cells streaming in interlacing fascicles and intersecting with cells from adjacent aggregates giving a storiform pattern, in 10× magnification [Figure 1].{Figure 1}Connective tissue exhibits numerous aggregates of streaming interlacing fascicles at various foci of the section, in 10× magnification [Figure 2].{Figure 2}Intersecting fascicles of plump spindle-shaped fibroblast-like cells exhibiting pleomorphism and hyperchromatism, in 40× magnification [Figure 3].{Figure 3}The spindle-shaped cells show marked hyperchromatism, nuclear pleomorphism, and increased mitotic activity, under 40× magnification [Figure 4].{Figure 4}Areas of hemorrhage and necrosis were found amidst the malignant connective tissue cells, under 10× magnification [Figure 5].{Figure 5}Immunohistochemistry was done with markers vimentin and CD68. Malignant cells showed strong positivity for vimentin and moderate positivity for CD68, as shown in [Figure 6] and [Figure 7], respectively.{Figure 6}{Figure 7}

 Diagnosis



Undifferentiated pleomorphic sarcoma (malignant fibrous histiocytoma).

 Conclusion





Storiform variant malignant fibrous histiocytoma mimics all poorly differentiated malignancies, and is identified by using immunohistochemical markers.

 Acknowledgment



We thank Dr. Prathiba Ramani, MDS, Professor, Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals.