Journal of Oral and Maxillofacial Pathology

REVIEW ARTICLE
Year
: 2012  |  Volume : 16  |  Issue : 2  |  Page : 251--255

Toluidine blue: A review of its chemistry and clinical utility


Gokul Sridharan, Akhil A Shankar 
 Department of Oral Pathology and Microbiology, YMT Dental College and Hospital, Kharghar, Navi Mumbai, Maharashtra, India

Correspondence Address:
Gokul Sridharan
Department of Oral Pathology and Microbiology, YMT Dental College and Hospital, Institutional Area, Sector 4, Kharghar, Navi Mumbai- 410 210, Maharashtra
India

Toluidine blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components, thereby staining tissues rich in DNA and RNA. It has found wide applications both as vital staining in living tissues and as a special stain owing to its metachromatic property. Toluidine blue has been used in vivo to identify dysplasia and carcinoma of the oral cavity. Use of toluidine blue in tissue sections is done with the aim to highlight components, such as mast cells granules, mucins, and cartilage. This article provides an overview on chemistry, technique, and the various applications of toluidine blue.


How to cite this article:
Sridharan G, Shankar AA. Toluidine blue: A review of its chemistry and clinical utility.J Oral Maxillofac Pathol 2012;16:251-255


How to cite this URL:
Sridharan G, Shankar AA. Toluidine blue: A review of its chemistry and clinical utility. J Oral Maxillofac Pathol [serial online] 2012 [cited 2019 Dec 9 ];16:251-255
Available from: http://www.jomfp.in/article.asp?issn=0973-029X;year=2012;volume=16;issue=2;spage=251;epage=255;aulast=Sridharan;type=0