Journal of Oral and Maxillofacial Pathology

REVIEW ARTICLE
Year
: 2012  |  Volume : 16  |  Issue : 1  |  Page : 73--78

Potential role of septins in oral carcinogenesis: An update and avenues for future research


Rooban Thavarajah, KM Vidya, Elizabeth Joshua, Umadevi K Rao, K Ranganathan 
 Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, India

Correspondence Address:
Rooban Thavarajah
Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai 600 119
India

Septins belong to the GTPase superclass of conserved proteins and have been identified to play a role in diverse aspects of cell biology, from cytokinesis to the maintenance of cellular morphology. At least 14 septins have been identified in humans. With their complex patterns in gene expressions and interaction, it has been reported that alterations in septin expression are observed in human diseases. Although much is not known about the role of human septins in oral carcinogenesis, circumstantial evidence does indicate that it may play a major role. This review intends to summarize the basis of septin biology, with the focus being on the evidence for septin involvement in human oral cancer.


How to cite this article:
Thavarajah R, Vidya K M, Joshua E, Rao UK, Ranganathan K. Potential role of septins in oral carcinogenesis: An update and avenues for future research.J Oral Maxillofac Pathol 2012;16:73-78


How to cite this URL:
Thavarajah R, Vidya K M, Joshua E, Rao UK, Ranganathan K. Potential role of septins in oral carcinogenesis: An update and avenues for future research. J Oral Maxillofac Pathol [serial online] 2012 [cited 2020 Aug 11 ];16:73-78
Available from: http://www.jomfp.in/article.asp?issn=0973-029X;year=2012;volume=16;issue=1;spage=73;epage=78;aulast=Thavarajah;type=0