Journal of Oral and Maxillofacial Pathology

: 2006  |  Volume : 10  |  Issue : 1  |  Page : 9-

Know this field

B Kavitha, G Sivakumar, TR Saraswathi 
 Department of Oral and Maxillo Facial Pathology, Meenakshi Ammal dental college and hospital, Chennai, India

Correspondence Address:
B Kavitha
Department of Oral and Maxillo Facial Pathology, Meenakshi Ammal dental college and hospital, Chennai

How to cite this article:
Kavitha B, Sivakumar G, Saraswathi T R. Know this field.J Oral Maxillofac Pathol 2006;10:9-9

How to cite this URL:
Kavitha B, Sivakumar G, Saraswathi T R. Know this field. J Oral Maxillofac Pathol [serial online] 2006 [cited 2020 Jul 8 ];10:9-9
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Case details

A 22-year-old male patient reported with a swelling of left lower jaw of 1 %2 months duration. On clinical examination, a diffuse bony swelling extended from 34 region to coronoid process. Multiple radiolucency seen in left side of the mandible.

Microscopic findings

Pleomorphic cells arranged in intersecting fascicles in storiform patternAltered N/C ratio and mitotic figuresFocal myxoid areas with numerous multinucleated giant cellsChronic inflammatory cell infiltrate, predominantly lymphocytesOccasional rounded histiocytesStroma with delicate collagen network

Provisional diagnosis

Malignant fibrous histiocytoma (MFH)

Differential diagnosis

Pleomorphic liposarcoma

Usually lacks a distinct whorled / storiform patternContains less stromal collagenVacuolated lipoblasts with scalloped nuclei seen in contrast to the finely dispersed fat and undisplaced nucleus in histiocytes of MFH

Pleomorphic rhabdomyosarcoma

Cells have uniform and deeply eosinophilic cytoplasm, longitudinal striations with less interstitial collagenization


Cells are uniformly spindle shaped and vary little in size and shapeMultinucleated giant cells is a rare feature of this tumourMarked nuclear pleomorphism is more suggestive of MFH than fibrosarcoma

MPNST (Malignant peripheral nerve sheath tumour)

Cells have a wavy appearance compared to the finely tapered fibroblastsLong sweeping fascicles are usually not presentCartilagenous metaplasia is more frequent than any other non-cartilagenous neoplasm

Fibroblastic Osteosarcoma

Tumour cells are spindle shaped with focal areas of matrix production

Dediffentiated Chondrosarcoma

Lobules of hyaline cartilage juxtaposed with spindle cell foci

Absence of vacuolated lipoblasts, striated cells, wavy nucleated cells, focal areas of matrix formation and cartilaginous areas rule out above said lesions.

Final diagnosis

Malignant fibrous histiocytoma (Pleomorphic - storiform variant)