Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contact Us Login 
An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
  Table of Contents    
ONLINE ONLY ARTICLES - CASE REPORT  
Year : 2020  |  Volume : 24  |  Issue : 2  |  Page : 404
 

Basal cell adenoma of sublingual salivary gland: A rare entity


1 Department of Prosthodontics, Shri Lal Bahadur Shastri Government Medical College and Hospital, Mandi, Himachal Pradesh, India
2 Department of Oral and Maxillofacial Surgery, Shri Lal Bahadur Shastri Government Medical College and Hospital, Mandi, Himachal Pradesh, India
3 Department of Oral and Maxillofacial Pathology, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
4 Department of Oral Medicine and Radiology, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India

Date of Submission16-May-2020
Date of Decision11-Jun-2020
Date of Acceptance13-Jun-2020
Date of Web Publication09-Sep-2020

Correspondence Address:
Sanjeev Malhotra
Shri Lal Bahadur Shastri Government Medical College and Hospital, Nerchowk, Mandi, Himachal Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_210_20

Rights and Permissions

 

   Abstract 


Monomorphic adenoma or Basal cell adenoma (BCA) is a benign epithelial tumor of glandular origin. It has very unique histological characteristic and its diagnosis is mainly established by histological examination. Most common occurrence is in parotid gland and rarely reported in submandibular and sublingual salivary glands. In this case report, we are presenting a case of basal cell adenoma of sublingual gland.


Keywords: Basal cell adenoma, monomorphic adenoma, sublingual gland


How to cite this article:
Sirohi R, Malhotra S, Wadhwan V, Malik S. Basal cell adenoma of sublingual salivary gland: A rare entity. J Oral Maxillofac Pathol 2020;24:404

How to cite this URL:
Sirohi R, Malhotra S, Wadhwan V, Malik S. Basal cell adenoma of sublingual salivary gland: A rare entity. J Oral Maxillofac Pathol [serial online] 2020 [cited 2020 Sep 20];24:404. Available from: http://www.jomfp.in/text.asp?2020/24/2/404/294615





   Introduction Top


Basal cell adenoma (BCA) is an unusual type of benign epithelial salivary gland tumor and classified as a type of monomorphic adenoma. It has unique histopathological characteristics. BCA accounts for only 1%–3% of all salivary gland tumors. It is included in 1991 World Health Organization classification, as a separate entity.[1] Most frequent location of this tumor is parotid gland. About 80% of cases occur in parotid only.[2] However, it can also involve upper lip, buccal mucosa, lower lip, palate and nasal septum.[3],[4] In this case report, we present a case of BCA of sublingual salivary gland.


   Case Report Top


A 64-year-old female patient reported to the Department of Dentistry, Shri Lal Bahudur Shastri Government Medical College and Hospital, Nerchowk at Mandi, Himachal Pradesh, with the chief complaint of a painless swelling in the mouth for 1 year.

Intraoral examination revealed moderately firm, well-defined, ovoid, solitary swelling in the left sublingual region measuring approximately 3 cm × 2 cm [Figure 1]. Swelling was mobile on bimanual palpation.
Figure 1: Clinical location of the lesion in the sublingual region

Click here to view


Occlusal view revealed no sign of erosion and no bony destruction of adjacent structures. Excisional biopsy was done and the excised specimen was sent for histopathological examination. The H&E-stained sections at ×4 showed a well-circumscribed tumor mass [Figure 2]. Tumor cells were arranged in small clusters, cords and trabeculae and at places forming microglandular patterns [Figure 3]. Cells with uniform round to oval nuclei with scanty cytoplasm, bland nuclear chromatin with inconspicuous nucleoli were seen [Figure 4]. Intervening stroma showed inflammatory cells, blood capillaries and few areas of hemorrhage [Figure 5]. The histopathological features were suggestive of BCA.
Figure 2: H&E, ×4 – Stained sections showed circumscribed tumor

Click here to view
Figure 3: H&E, ×10 – Tumor cells arranged in small clusters forming microglandular patterns

Click here to view
Figure 4: H&E, ×40 – Cells with uniform round to oval nuclei with scanty cytoplasm and inconspicuous nucleoli

Click here to view
Figure 5: H &E, ×10 – Stroma with inflammatory cells, blood capillaries and areas of hemorrhage

Click here to view



   Discussion Top


BCA has a low incidence, i.e., 1%–3% of all salivary gland tumors, and peak incidence is generally in the seventh decade of life with marked female predilection.[5] Clinical presentation of BCA is a slow-growing, asymptomatic and freely movable swelling. In general, such tumors do not exceed size of 3 cm.[4]

The diagnosis of BCA must be confirmed only by histopathological examination. It is a benign epithelial tumor having cells derived from glandular epithelium and lack the characteristic myxochondroid matrix found in pleomorphic adenoma.[1],[6]

On the basis of morphological pattern, BCAs are classified into four types: solid, trabecular, tubular and membranous. Solid variant is the most common one.[1] In our case, tumor had predominant trabecular pattern with hyperchromatic chromatin and scanty stroma.

Diagnosis of BCA is of clinical importance as it affects treatment and prognosis of the lesion. These tumors are amenable for conservative treatment such as local excision or only superficial removal of affected gland.


   Conclusion Top


BCA of sublingual salivary gland is a rare occurrence. In this case, differential diagnosis was pleomorphic adenoma and adenoid cystic carcinoma. Histopathological examination of the lesion after excisional biopsy was of utmost importance for diagnosis of the tumor as it has prognostic implications.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Seifert G. Histological typing of salivary gland tumours. In: Histological Typing of Salivary Gland Tumours. Berlin, Germany; Springer: 1991.  Back to cited text no. 1
    
2.
Lin HC, Chien CY, Huang SC, Su CY. Basal cell adenoma of the sublingual gland. Ann Otol Rhinol Laryngol 2003;112:1066-8.  Back to cited text no. 2
    
3.
Mintz GA, Abrams AM, Melrose RJ. Monomorphic adenomas of the major and minor salivary glands: Report of twenty-one cases and review of the literature. Oral Surg Oral Med Oral Pathol 1982;53:375-86.  Back to cited text no. 3
    
4.
Bernacki EG, Batsakis JG, Johns ME. Basal cell adenoma: Distinctive tumor of salivary glands. Arch Otolaryngol 1974;99:84-7.  Back to cited text no. 4
    
5.
Hiranuma T, Kagamiuchi H, Kitamura R. A basal cell adenoma of the sublingual gland. Int J Oral Maxillofac Surg 2003;32:566-7.  Back to cited text no. 5
    
6.
Canalis RF, Mok MW, Fishman SM, Hemenway WG. Congenital basal cell adenoma of the submandibular gland. Arch Otolaryngol Head Neck Surg. 1980;106:284-6.  Back to cited text no. 6
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]



 

Top
Print this article  Email this article
            

    

 
   Search
 
  
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Article in PDF (2,250 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
   Introduction
   Case Report
   Discussion
   Conclusion
    References
    Article Figures

 Article Access Statistics
    Viewed22    
    Printed0    
    Emailed0    
    PDF Downloaded16    
    Comments [Add]    

Recommend this journal

Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007