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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
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Year : 2020  |  Volume : 24  |  Issue : 2  |  Page : 400-401
The efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide-induced squamous cell carcinoma of the tongue in rats


1 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Başkent University, İstanbul, Turkey
2 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Medipol University, İstanbul, Turkey
3 Department of Pathology, Faculty of Medicine, Başkent University, İstanbul, Turkey
4 Pathology Laboratory, Council of Forensic Medicine, Ankara Group Chairmanship, İstanbul, Turkey
5 Animal Research Center, Başkent University, İstanbul, Turkey

Correspondence Address:
Secil Cubuk
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, 11 Sokak No: 26 Bahçelievler, Ankara 06490
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_88_18

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Aims: The aim of this study to investigate the efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinogenesis of the tongue in rats. Subjects and Methods: The sample was composed of 27 male Sprague Dawley rats that received 50 ppm 4NQO for 20 weeks in drinking water. Group 1 (n = 9) was treated with 50 mg/kg/day propranolol for 20 weeks, Group 2 (n = 9), after carcinogenesis inducement for 20 weeks, received propranolol (50 mg/kg/day) for 2 weeks and Group 3 (n = 9) received no treatment. At the end of the experimental stage, the tongue specimens were evaluated under a light microscope and categorized as low- or high-risk lesions according to a binary system. Statistical Analysis Used: The statistical comparison was performed with a likelihood ratio test. Results: Histopathological analysis revealed the risk of malignant transformation rates as 33.3% in Group 1, 55.5% in Group 2 and 77.8% in Group 3; however, the difference between the groups was not statistically significant (P > 0.05). Conclusion: The results of the study suggest that propranolol has a tendency to preventive effect against carcinogenesis.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007