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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
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Year : 2020  |  Volume : 24  |  Issue : 1  |  Page : 186
Galectin-1 expression in oral squamous cell carcinoma: An immunohistochemical study


1 Department of Oral and Maxillofacial Pathology, MGV's K.B.H. Dental College and Hospital, Nashik, Maharashtra, India
2 Department of Oral Pathology and Microbiology, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of, Saudi Arabia

Correspondence Address:
Vaibhavi Salunkhe
Department of Oral and Maxillofacial Pathology, MGV's K.B.H. Dental College and Hospital, Nashik - 422 003, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_240_19

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Context: Oral squamous cell carcinoma (OSCC) of the head and neck are a heterogeneous group of neoplasms with an increasing rate of mortality and morbidity. OSCCs are characterized by a high degree of local invasiveness and metastasis to cervical lymph nodes but show a lower rate of distant metastasis. Galectin-1 (Gal-1), a β-galactoside-binding lectin, is known to regulate tumor cell growth, angiogenesis, mediate cell-cell or cell-extracellular matrix adhesion and promote cancer cell migration. Aims: This study aims to evaluate the Gal-1 expression in different clinical stages and histological grades of OSCC. Settings and Design: Forty histopathologically diagnosed cases of OSCC, including 16 cases of well-differentiated, 18 moderately differentiated and 6 poorly differentiated carcinomas, were included in the study group. Materials and Methods: The samples were subjected to staining using primary mouse monoclonal antibodies against Gal-1 and visualized using polymer-HRP detection system. Statistical Analysis: The nonparametric Mann–Whitney U-test and Kruskal–Wallis ANOVA test were used for the statistical analysis. Results: Gal-1 expression was higher in advanced stages of OSCC, and the results were statistically significant. Immunoexpression of Gal-1 increased with advancing histological grades of OSCC with statistically significant results. Conclusion: Gal-1 plays an important role in invasion, metastasis and as a prognostic marker.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
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