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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
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Year : 2019  |  Volume : 23  |  Issue : 3  |  Page : 443-449
Glucose transporter 1 in health and disease


1 Department of Oral Pathology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India
2 Head of the Department, Department of Oral Pathology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India

Correspondence Address:
Sindhuri Pragallapati
Sri Chaitanya Dental Clinic, Near RTC Bus Stand, Jangareddygudem - 534 447, West Godavari, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_22_18

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Glucose, a major source of energy for all cells, is transported into cells with the help of glucose transporters (GLUTs). These transporters are of two types, namely sodium-dependent GLUTs and facilitative GLUTs. These transporters are present in a tissue-specific pattern and have substrate specificity. Among these transporters, GLUT1 (facilitative GLUT) is present ubiquitously on all tissues of the body and helps in the basal uptake of glucose. GLUT1 is known to have many physiological functions in the body from the time of implantation of an embryo and is also seen associated with pathologies, including cancers. This review mainly focuses on GLUT1 in physiological and pathological conditions and the recent advances related to its role in cancer development and applications in cancer therapeutics.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007