|Year : 2019 | Volume
| Issue : 3 | Page : 429-431
Intraoral salivary duct cyst: Report of rare entity
Saurabh R Nagar1, Nishant L Pandey2, Shivani Bansal3, Rajiv S Desai3
1 Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai, Maharashtra, India
2 Private Practitioner, Thane, Maharashtra, India
3 Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, Maharashtra, India
|Date of Submission||16-Jun-2019|
|Date of Acceptance||05-Aug-2019|
|Date of Web Publication||19-Dec-2019|
Saurabh R Nagar
Assistant Professor, Department of Oral Pathology and Microbiology, Government Dental College and Hospital, St. George Hospital Campus, Near Chhatrapati Shivaji Terminus Area, Mumbai - 400 001, Maharashtra
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Salivary duct cysts (SDCs) are true cysts caused by obstruction of the salivary ducts and are rare in minor salivary glands. A 62-year-old male reported with a painless swelling in the left buccal mucosa for 2 years. Excision of the entire lesion was performed under local anesthesia following which histopathological examination was performed. Microscopically, a dilated salivary gland duct composed of 1–2 layers of cuboidal cells with intraluminal mucous plug was observed. Cystic lumen lined by mucous cells, squamous cells and ciliated cells was seen. Oncocytic metaplasia was also present at various places. Histopathologically, it was consistent with the diagnosis of SDC. Intraoral SDCs and mucoceles clinicopathologically mimic salivary gland neoplasms, making diagnosis difficult and subject to errors in treatment. It is important for oral and maxillofacial surgeons to include SDC in the differential diagnosis of swelling affecting buccal mucosa.
Keywords: Buccal mucosa, metaplasia, salivary duct cyst
|How to cite this article:|
Nagar SR, Pandey NL, Bansal S, Desai RS. Intraoral salivary duct cyst: Report of rare entity. J Oral Maxillofac Pathol 2019;23:429-31
|How to cite this URL:|
Nagar SR, Pandey NL, Bansal S, Desai RS. Intraoral salivary duct cyst: Report of rare entity. J Oral Maxillofac Pathol [serial online] 2019 [cited 2020 Jan 23];23:429-31. Available from: http://www.jomfp.in/text.asp?2019/23/3/429/273487
| Introduction|| |
Cystic lesions represent around 6%–9% of the total salivary gland disorders, particularly in the major salivary glands. The salivary duct cyst (SDC), also known as sialocyst, is an acquired cystic dilatation of salivary ducts that are thought to arise secondary to ductal obstruction, which may be transient or persistent., Various terminologies may be used to denominate these lesions; however, “SDC” is the most adequate by virtue of its origin being related to the epithelial lining of salivary gland ducts. SDCs typically occur in the major salivary glands mainly in the parotid, where they present as unilateral, asymptomatic, compressible nodules in adult patients. Its occurrence in minor salivary gland is rare and occurs more commonly in the sixth decade of life. We report a rare case of SDC of the buccal mucosa in a 62-year-old male.
| Case Report|| |
A 62-year-old healthy man was reported with a gradually increasing swelling in the left buccal mucosa of 2 years duration. While eating, there was no pain or increase in the size of swelling. Intraoral examination revealed painless, mobile, noncompressible, soft, nodular, solitary swelling measuring approximately 10 mm × 12 mm on bimanual palpation. The differential diagnosis of mucocele and salivary gland neoplasm were considered. A provisional diagnosis of mucocele was made, and excisional biopsy of the lesion was performed under local anesthesia followed by histopathological evaluation. Gross examination revealed soft brownish cystic sac filled by slimy gel-like material [Figure 1].
|Figure 1: Clinical image showing surgical exposure of salivary duct cyst in the left buccal mucosa (Inset: gross specimen showing cystic sac filled with slimy gel-like material)|
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H and E-stained sections revealed dilated salivary gland duct with intraluminal mucous plug [Figure 2]. The cystic lumen was lined by one to two layers of cuboidal-columnar mucinous epithelium exhibiting mucous cells, squamous cells and ciliated cells resembling maxillary sinus lining and oncocytic metaplasia at various places [Figure 3]. Dense chronic inflammatory infiltrate composed chiefly of lymphocytes was seen around the dilated duct. Cystic lining also showed mucopapillary projections in some areas and acini of the salivary gland mucosa exhibiting discrete atrophy. Postoperative healing was uneventful.
|Figure 2: Histopathological image showing cystically dilated salivary gland duct with intraluminal mucous plug and squamous metaplasia of the lining epithelium (H & E, ×100)|
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|Figure 3: Histopathological image revealing cystic lining exhibiting ciliated, mucous and oncocytic metaplasia (H & E, ×400)|
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| Discussion|| |
The pathogenesis of the SDC is still uncertain. It is believed that with the increase in age, there is a natural reduction in salivary secretion, promoting the formation of a mucous plug that causes partial or total obstruction of the salivary gland duct, resulting in dilation of the duct and increase in intraluminal pressure., Although various terminologies such as mucoceles and mucous retention cyst were used to denominate these lesions, the term “SDC” is the most preferable for several reasons. Mucous retention cyst does not adequately describe the phenotypic variation seen in these cysts, whereas SDCs are already commonly used to describe these cysts in the major salivary glands associated with the salivary duct.
SDCs may present clinical-pathological characteristics similar to those of salivary gland pathologies such as mucocele, pleomorphic adenoma, cystadenoma and low-grade mucoepidermoid carcinoma, making diagnosis difficult and subject to errors in treatment.
Clinically, both mucocele and SDC represents as an asymptomatic nodule, but later one is rare in occurrence. Mucoceles can be clinically differentiated from SDCs, having the site of predilection more common on lower lip mucosa (59%–82%), which is a prone site for trauma. SDCs occur on mucosa less prone to trauma include floor of the mouth, soft and hard palate, mandibular vestibule and contiguous areas of the buccal mucosa. Mucoceles occur in younger age group belong to first to fourth decades of life against SDCs having common occurrence in the sixth decade.,,
Histologically, SDCs show cystic cavity lined by 1–2 layers of cuboidal or columnar epithelium, consistent with normal salivary duct architecture. Metaplastic changes occur often in the cystic epithelium of the SDC, wherein most commonly reported are oncocytic (50.8%) followed by mucous cell (36.2%), squamous (23.7%), ciliated cell (16.4%) and apocrine-like (14.1%) metaplasia. The present case demonstrated oncocytic, mucous, squamous and ciliated metaplasia at various places. Intraoral SDCs are reactive ductal ectasia that develops secondary to intraluminal obstruction. Intraluminal calcification foci are rare as approximately half of SDCs show patent lumens and stasis resolving transiently.
Although the occurrence of SDC is rare in the oral cavity, it is important to include it in the differential diagnosis of a cystic lesion affecting buccal mucosa, especially in geriatric patients.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Antoniades D, Epivatianos A, Markopoulos A, Kolokotronis A, Zaraboukas T. Coexistence of mucous retention cyst and basal cell adenoma arising from the lining epithelium of the cyst. Report of two cases. Med Princ Pract 2009;18:248-52.
Work WP. Cysts and congenital lesions of the parotid gland. Otolaryngol Clin North Am 1977;10:339-43.
Batsakis JG, Raymond AK. Sialocysts of the parotid glands. Ann Otol Rhinol Laryngol 1989;98:487-9.
Chi AC, Lambert PR 3rd
, Richardson MS, Neville BW. Oral mucoceles: A clinicopathologic review of 1,824 cases, including unusual variants. J Oral Maxillofac Surg 2011;69:1086-93.
Hruban RH, Pitman MB, Klimstra DS. Tumors of the Pancreas. Washington DC: American Registry of Pathology, Armed Forces Institute of Pathology (US); 2007.p. 422.
Hayashida AM, Zerbinatti DC, Balducci I, Cabral LA, Almeida JD. Mucus extravasation and retention phenomena: A 24-year study. BMC Oral Health 2010;10:15.
Eversole LR. Oral sialocysts. Arch Otolaryngol Head Neck Surg 1987;113:51-6.
Seifert G. Mucoepidermoid carcinoma in a salivary duct cyst of the parotid gland. Contribution to the development of tumours in salivary gland cysts. Pathol Res Pract 1996;192:1211-7.
Stojanov IJ, Malik UA, Woo SB. Intraoral salivary duct cyst: Clinical and histopathologic features of 177 cases. Head Neck Pathol 2017;11:469-76.
[Figure 1], [Figure 2], [Figure 3]