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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2019  |  Volume : 23  |  Issue : 3  |  Page : 349-355
Calretinin expression in odontogenic cysts and odontogenic tumors and the possible role of calretinin in pathogenesis of ameloblastoma

1 Department of Oral and Maxillofacial Pathology, Navodaya Dental College and Hospital, Raichur, Karnataka, India
2 Department of Oral and Maxillofacial Pathology, Drs. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Vijayawada, Andhra Pradesh, India
3 Department of Oral and Maxillofacial Pathology, Government Dental College, Vijayawada, Andhra Pradesh, India
4 OMFS and Diagnostic Sciences, College of Dentistry, King Faisal University, Al-Ahasa, Saudi Arabia
5 Department of Oral and Maxillofacial Pathology, GSL Dental College, Rajahmundry, Andhra Pradesh, India

Correspondence Address:
Amrutha Rudraraju
Department of Oral and Maxillofacial Pathology, Navodaya Dental College and Hospital, Raichur - 584 103, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jomfp.JOMFP_54_19

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Introduction: Histopathological diagnosis of odontogenic cysts and tumors is a task mostly accomplished with hematoxylin and eosin staining. However, the use of additional diagnostic modalities such as immunohistochemistry may be necessary in histologically similar lesions. The reports of studies which have used calretinin as an immunohistochemical marker for ameloblastoma have been conflicting. Aim: The aim of the study was to evaluate the use of calretinin as a specific diagnostic marker for ameloblastoma and observe its expression in odontogenic cysts and other odontogenic tumors. Materials and Methods: Formalin-fixed, paraffin-embedded sections were taken from the archives which included 15 cases each of dentigerous cyst, radicular cyst, odontogenic keratocyst and ameloblastoma five cases of adenomatoid odontogenic tumor and three cases of ameloblastic carcinoma. Immunohistochemistry was done with calretinin antibody. Results: All ameloblastomas were positive for calretinin, whereas no other tumor or cyst showed positivity. Differences in proportion of calretinin expression were statistically significant with P = 0.000. Conclusion: Calretinin can be considered as a specific marker for ameloblastomas.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007