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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
INVITED REVIEW Table of Contents   
Year : 2019  |  Volume : 23  |  Issue : 3  |  Page : 318-323
Tumor budding is a potential histopathological marker in the prognosis of oral squamous cell carcinoma: Current status and future prospects


Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research, Belgaum, Karnataka, India

Correspondence Address:
Punnya V Angadi
Department of Oral Pathology and Medicine, KLEVK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research, Belgaum - 590 010, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_331_19

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Tumor budding (TB) is a histopathologically evident feature that represents a scattered pattern of invasion consisting of isolated single tumor epithelial cells or tumor cells in small clusters (up to 5 cells) seen primarily at the invasive front dispersed within the stroma for variable distance. Presence of TB has been linked with lymph node metastasis, recurrence, distant metastasis and reduced survival in numerous cancers including oral squamous cell carcinoma (OSCC). Tumor buds are also considered as histopathological markers of epithelial–mesenchymal transition which is a molecular process implicated as a hallmark for invasion and metastasis. This review gives an overview of the current evidence regarding TB assessment in OSCC and its future prospects.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
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