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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
CASE REPORT Table of Contents   
Year : 2019  |  Volume : 23  |  Issue : 2  |  Page : 284-288
Diffuse large B-cell lymphoma: An immunohistochemical approach to diagnosis


Department of Oral and Maxillofacial Pathology and Oral Microbiology, I.T.S. Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India

Correspondence Address:
Aashka Sethi
Department of Oral and Maxillofacial Pathology and Oral Microbiology, I.T.S. Centre for Dental Studies and Research, Muradnagar, Ghaziabad - 201 206, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_294_18

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Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of non-Hodgkin's lymphoma (NHL) that develops from the B-cells of the lymphatic system. It is the most common subtype of NHL accounting for 30%–40% of all cases. In addition to determining if NHL is indolent or aggressive and whether it is B-cell, T-cell or NK-cell lymphoma, it is very important to determine the subtype of NHL. This is because each subtype can behave differently and may require different treatments. This warrants the need for an accurate and explicit subtype-specific diagnosis that catalogs the molecular prognostic indicators. Moreover, retrospective studies have confirmed that diagnosis to treatment interval is strongly associated with prognostic clinical factors and outcome in newly diagnosed cases of DLBCL. Therefore, an expeditious histological and immunohistochemical investigation should be compassed in cases of oral lymphomas.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
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