Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contact Us Login 
An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2019  |  Volume : 23  |  Issue : 2  |  Page : 192-197
Salivary calcium as a diagnostic tool for screening of osteoporosis in postmenopausal women

1 Department of Oral Pathology, KLE VK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research, KLE University, Belagavi, Karnataka, India
2 Department of Periodontology, KLE VK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research, KLE University, Belagavi, Karnataka, India

Correspondence Address:
Shweta Vinayak Kumbhojkar
Department of Oral Pathology, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi - 590 010, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jomfp.JOMFP_133_19

Rights and Permissions

Background: Women's health undergoes physiological, pathological and psychological changes after menopause. Reduced estrogen levels have been implicated in the pathogenesis of osteoporosis in postmenopausal women. Estrogen is also known to affect the salivary gland functions. To understand the association between serum estrogen, osteoporosis and salivary calcium, the present cross-sectional study was undertaken. Aim: The aim of this study is to determine salivary calcium levels and its use for the diagnosis of osteoporosis in postmenopausal women. Methodology: Ninety individuals divided into three groups of healthy controls, pregnant women and postmenopausal women were selected. Serum estrogen, salivary calcium and bone mineral density (BMD) at the heel region were estimated. Statistical analysis using the Mann–Whitney U-test was done to compare the results within the groups. Results: Mean estrogen levels were 115.8 ± 80.18 pg/mmol in control group, 7729.4 ± 907.6 pg/mmol in pregnant group and 51.2 ± 74.51 pg/mmol in postmenopausal group, respectively. The mean salivary calcium in control, pregnant and postmenopausal groups was 3.12 ± 0.63, 3.19 ± 0.62 and 7.12 ± 0.79 μg/dl, respectively. Paired comparison within the groups showed high statistical significance (P = 0.0000) in the salivary calcium levels. The mean BMD of −2.3 (standard deviation [SD] ± 0.83) in the postmenopausal group was significantly lower than −0.6 (SD ± 0.99) and −0.2 (SD ± 1.42) of pregnant and control groups, respectively. Conclusion: A negative correlation was found between estrogen and bone density. A significant difference in salivary calcium was noted in the study groups, highlighting the role of salivary calcium in the detection of early bone changes in postmenopausal women.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded118    
    Comments [Add]    

Recommend this journal


Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007