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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
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Year : 2018  |  Volume : 22  |  Issue : 3  |  Page : 446
Immunohistochemical expression of osteonectin, matrix metalloproteinases-9 and Ki-67 in ameloblastoma


1 Department of Oral and Maxillofacial Pathology and Microbiology, CKS Theja Institute of Dental Science and Research, Tirupati, Andhra Pradesh, India
2 Department of Oral and Maxillofacial Pathology and Microbiology, Narayana Dental College, Nellore, Andhra Pradesh, India
3 Department of Oral and Maxillofacial Pathology and Microbiology, Anil Neerukonda Institute of Dental Sciences, Visakhapatnam, Andhra Pradesh, India
4 Department of Oral Medicine and Radiology, Anil Neerukonda Institute of Dental Sciences, Visakhapatnam, Andhra Pradesh, India
5 Department of Periodontics, Anil Neerukonda Institute of Dental Sciences, Visakhapatnam, Andhra Pradesh, India

Correspondence Address:
K Indirapriyadarsini
Department of Oral and Maxillofacial Pathology and Microbiology, CKS Theja Institute of Dental Science and Research, Tirupati - 517 520, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_271_17

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Background: Ameloblastoma (AM) is a benign odontogenic neoplasm characterized by local invasiveness and recurrence. We have evaluated the immunohistochemical expressions of osteonectin (ON), matrix metalloproteinase-9 (MMP-9) and Ki-67 in AM to understand the biologic behavior of this neoplasm. Aim: The aim of this study is to evaluate the expression of ON, MMP-9 and Ki-67 in AM. Materials and Methods: The study sample included archival tissues embedded in paraffin blocks histopathologically diagnosed as AM (20 cases). Three serial sections of each tissue specimen were stained separately with ON, MMP-9 and Ki-67 (immunohistochemistry stain) and evaluated. The data were analyzed using Spearman rank correlation test. Results: All AM cases 20/20 (100%) exhibited positive immunostaining for ON, MMP-9 and Ki-67. Conclusion: Increased expression of ON, MMP-9 and Ki-67 in AM indicates that these molecules might play a role in the regulation and aggressive nature of this neoplasm.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007