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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
REVIEW ARTICLE Table of Contents   
Year : 2018  |  Volume : 22  |  Issue : 3  |  Page : 367-374
Stem-cell therapy and platelet-rich plasma in regenerative medicines: A review on pros and cons of the technologies


1 Department of Oral Pathology, MMNG Halgekar Institute of Dental Science, Belagavi, Karnataka, India
2 Center for Incubation, Innovation, Research and Consultancy, Jyothy Institute of Technology, Bengaluru, Karnataka, India
3 Department of Oral Pathologist, Chaitanya Dental Clinic, Bengaluru, Karnataka, India
4 General and Laparoscopic Surgeon, SSNMC Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Shwetha Hulimavu Ramaswamy Reddy
Department of Oral Pathology, MMNG Halgekar Institute of Dental Science, Belagavi, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_93_18

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Regenerative medicine encompasses new emerging branch of medical sciences that involves the functional restoration of tissues or organs caused by severe injuries or chronic diseases. Currently, there are two contending technologies that can repair and restore the damaged tissues, namely platelet-rich plasma (PRP)- and stem cell (SC)-based therapies. PRP is a component of blood that contains platelet concentrations above the normal level and includes platelet-related growth factors and plasma-derived fibrinogen. Platelets are the frontline healing response to injuries as they release growth factors for tissue repair. SCs, on the other hand, are the unspecialized, undifferentiated, immature cells that based on specific stimuli can divide and differentiate into specific type of cells and tissues. Differentiated SCs can divide and replace the worn out or damaged tissues to become tissue- or organ-specific cells with specialized functions. Despite these differences, both approaches rely on rejuvenating the damaged tissue. This review is focused on delineating the preparation procedures, similarities and disparities and advantages and disadvantages of PRP- and SC-based therapies.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007