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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2018  |  Volume : 22  |  Issue : 2  |  Page : 163-167
Immunohistochemical study of salivary gland tumors in a tertiary institution in South-South Region of Nigeria

Department of Oral Pathology, UPTH, Port Harcourt, Nigeria

Correspondence Address:
Cornelius Azekanabo Iyogun
Department of Oral Pathology, UPTH, Port Harcourt
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jomfp.JOMFP_108_17

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Aim: The aim of this study was to see the usefulness of immunohistochemistry in diagnosing salivary gland tumors found in a tertiary health institution. Materials and Methods: Twenty-six formalin-fixed paraffin embedded salivary gland tumors were accessioned, and 2 μm were sectioned and processed using Streptavidin-Biotin immunoperoxidase method. Results: Adenoid cystic carcinoma (ADCC) was positive to alpha-smooth muscle actin (α-SMA) while mucoepidermoid carcinoma (MEC), polymorphous low-grade adenocarcinoma (PLGA), squamous cell carcinoma (SCC) and oncocytic carcinoma (OCC) were all negative to it. MEC, PLGA, ADCC and the only pleomorphic adenoma (PA) were positive to Ki-67 while both SCC and OCC were negative to it. All the tumors except PA were positive to p63. Conclusion: It appears that α-SMA may be used to distinguish ADCC from MEC and PLGA, but Ki-67 cannot be used for this purpose. Furthermore, p63 cannot help in the diagnosis of ADCC, MEC or PLGA. It was concluded that immunochemistry can be used as adjunct to routine H and E stain in the diagnosis of the various salivary gland tumors.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
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