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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
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Year : 2017  |  Volume : 21  |  Issue : 2  |  Page : 244-251
Alteration of cellular metabolism in cancer cells and its therapeutic prospects


Department of Oral Pathology and Microbiology, S.C.B. Dental College and Hospital, Cuttack, Odisha, India

Correspondence Address:
Biranchi Narayan Biswal
Department of Oral Pathology and Microbiology, S.C.B. Dental College and Hospital, Cuttack - 753 007, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_60_17

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Transformation of a normal cell into a cancerous phenotype is essentially backed by genetic mutations that trigger several oncogenic signaling pathways. These signaling pathways rewire the cellular metabolism to meet the bioenergetic and biomass requirement of proliferating cell, which is different from a quiescent cell. Although the change of metabolism in a cancer cell was observed and studied in the mid-20th century, it was not adequate to explain oncogenesis. Now, equipped with a revolution of oncogenes, we have a genetic basis to explain the transformation. Through several studies, it is clear now that such metabolic alterations not only promote cancer progression but also contribute to the chemoresistance of cancer. Targeting specific enzymes and combinations of enzymes can improve the efficacy of cancer therapy and help to overcome the therapeutic resistance.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007