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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2017  |  Volume : 21  |  Issue : 1  |  Page : 11-17
An in vitro study of isolation of candidal strains in oral squamous cell carcinoma patients undergoing radiation therapy and quantitative analysis of the various strains using CHROMagar


1 General Dental Practitioner, Vijayapur, India
2 Department of Oral Pathology, AECS Maaruti College of Dental Sciences and Research Center, Bengaluru, Karnataka, India

Correspondence Address:
Mohammad Mohsin Abdul Razak Ainapur
“AASHIYANA” Plot No. 16, Chandpur Colony, Vijayapur - 586 101, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.203793

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Background: Patients undergoing radiation therapy for oral squamous cell carcinoma (OSCC) have an increased risk of developing oral candidiasis. Radiation-induced hyposalivation is thought to be a major predisposing factor for it. Radiation therapy for 2–3 weeks leads to increase in the number of candidal species in the oral cavity, eventually leading to oral candidiasis. Objective: To evaluate and correlate the prevalence of candidal species in the oral cavity of OSCC patients and to compare with radiation dosage at 3rd and 6th week following radiotherapy. Materials and Methods: This study includes fifty patients undergoing radiation therapy for OSCC. Patients were examined at 3rd and 6th week following radiation therapy, and smear samples were obtained from lesional sites and the radiation dose was recorded. Smear samples were cultured on CHROMagar, and identification of various candidal species was done on the basis of colony color and their morphology. Results: The present study isolated four types of candidal species, namely, Candida albicans, Candida glabrata, Candida tropicalis and Candida krusei. All the organisms, except C. krusei, showed a significant increase from 3rd to 6th week of radiotherapy whereas C. glabrata and C. tropicalis showed a sudden exponential increase. Total radiation dosage did not show any correlation to candidal colonization at 3rd and 6th week following radiotherapy. Conclusion: OSCC patients undergoing radiotherapy show an increase in candidal colonization which is independent of radiation dosage and may be related to other factors. However, such findings should be further evaluated using a larger sample size.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007